I appreciate the can-do attitude of biohacking, but this is A. flatly wrong and B. a grave insult to every working pharma chemist.
Looking someone in the eye and asking them if they really are accusing me of watching some of my family members die from diabetes, cancer, and heart disease while I was hiding the cures and collecting my paycheck is an uncomfortable conversation, but I’ve had it a few times.
The only counterattack has been that no, they’re not saying that I personally have these things in my desk drawer, it’s the higher-ups, you know, them.
“So how have I been working on these diseases for 25 years without rediscovering any of these cures?” I ask, and that generally winds things up. But I like to think (or to kid myself) that I’ve planted a slight seed of doubt.
You need as much conviction in your voice as the quacks have, though, and that’s not easy, because they have a lot. Science has the evidence on its side, naturally, and that’s a lot, but conspiracy theorists and their friends have something to believe in, and that’s a very strong part of human nature indeed.
A toast to the dead / For children with cancer and AIDS / A cure exists and you probably could've been saved / Sad to see medicine divorce morality / Corporate home-wreckers pimpin' up the salary
An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.
A rare disease, also referred to as an "orphan disease", is any disease which affects a small percentage of the population. Most rare diseases are genetic
And yes, one of the incentives to encourage commercialization of orphan drugs is extended exclusivity.
It's a strange argument that the people of have world have easy access to pharma.
1. My immediate reaction was holy shit no, if a situation exists where your countrymen are trying to hack together potentially lethal drugs and medical procedures because you don't have facilities in place to save them, then whatever political decisions you are making, whatever trade deals you are signing, whatever wars you are fighting: stop ALL OF THAT SHIT AND FIX THIS FIRST.
2. Oh my god what a terrible way to die. I understand that this site is probably well-intentioned. I know that for someone with access to a pharmaceutical lab and who has experience in the small-scale manufacture of drugs intended for consumption by living creatures (experiments) including humans (clinical trials) it may make sense that we could just synthesise our own drugs. But failing to recognise that there are very real and very likely scenarios where people will die because you (or someone with your expertise) are not on hand to help them immediately if they fuck up.
I can't help but think that the existence of this site is a net harm to the world, there's just no way the risk calculation is the same between a chemical engineer and a regular chap who needs medication as to the possibility of just making it at home. Making it seem like this is a thing you think that you should do just sounds like bad advice.
But on the other hand, I'm so appalled by the ability of America as a nation to do terrible things such as let its citizens die from treatable illness, that this kind of makes sense. It just feels like the wrong problem to be solving.
I mean, how about focusing on fixing the broken medical system, avoiding killing all the people who aren't white and making it just a little harder for insane people to get guns. While you're at it, you might even want to try and drop "racist as shit" from the assumptions of the rest of the world about your country.
But that’s me groping for an upside. This speaks more than anything I could come up with what’s wrong with the current industry.
And maybe work on your country's persecution of homosexuals and aboriginals before you get on your high horse and point it at America.
While I don't really understand your point about showing gratitude.
1. Many of the major medical breakthroughs in recent history have nothing to do with "America", sure some of them might have happened there but that's hardly their defining factor.
2. Where in my comment did I imply that it was not disgraceful that American people where not enjoying the drugs we have in the modern world?
In terms of the whole homosexuality thing, no shit. It's also a problem that we are absolutely ruining the lives of the aboriginal population by throwing up barriers to progression and education at every turn and just treating them like second class citizens at best. Even worse that the way we treat our native citizens is how we treat refugees who we send to an unregulated island so we can beat the shit out of them and rape their children.
But just because there are parts of Australia that make me worry for this cesspit of inhumane bullshit, doesn't mean I can't also find it appalling that as a nation it seems impossible that america can't stop killing it's own citizens. Lethal weapons are sold at the local shopping centre, you can't get medical care even if you need it and God help you if your not white, you basically just need to factor "will get shot by police at some point" into your life plan.
Just because two countries are fucked up doesn't mean that you can't notice the stuff about another country and makes it fucked up alongside your own.
The major problem I have is with the implication that you can make your own drugs at home and it's safe, secondarily it's pretty concerning that there's actually a reader base for this information due to the countries healthcare system.
Pharmaceutical companies are paid just as much per unit in Australia. It's just funded by the taxpayer, under the assumption that healthy people will eventually pay tax.
> your country's persecution of homosexuals and aboriginals
I dunno, we've only had one major race riot this century(six total on Wikipedia), whereas the Wikipedia article for 'Mass racial violence in the United States' has eight in the same time period, and quite a few occurrences of 'This list is incomplete; you can help by expanding it.'
In terms of government action, we had a government apology(from the PM too, not just a motion passed) to the aboriginals before you had one to slaves(again, it wasn't done by a president). We haven't needed to apologise to slaves since they were either repatriated or properly integrated into society(again, one race riot this century).
In terms of homosexuality, Australia has possibly 88 murders of this nature, and no Wikipedia article dedicated to it, with approximately 150 instances since 1969(including a few mass shootings, which are a uniquely American problem). There has been some recent anti-gay propaganda, but that's due to a public vote on gay marriage, which is the sort of thing that would inflame divisions. Somehow, the argument has been on the suitability of homosexuals to raise children, and the risk of religious freedoms being restricted by poorly written legislation. We haven't had any signs saying "god hates fags" though.
I think Australia's doing pretty well.
Population of USA: 323.1 million (2016)
Population Density of Australia: 2 people per square mile
Population Density of USA: 84 people per square mile, with much higher density in some areas.
Your statistics are a little like saying "There sure are a lot more murders in the big city than in my small town!!!" If you aren't making any attempt to look at comparable data like per capita incidents, it is a classic case of how to lie with statistics (an excellent book, btw).
The US has 192 rural inhabitants per thousand, as opposed to 176 for Australia. Australia seems significantly more urbanised if anything. According to your logic, we should expect to see more hate crimes. That's not what happens though.
Wikipedia's list of ethnic riots has 134 entries for the US(since 1857, as that's the first Australian entry(there's more US entries in the dedicated article)), and 8 for Australia. That's 0.41 per million in the US, against 0.33 per million in Australia. The modern population should be fine as an approximation.
I'm going to insert mass shootings, because it's always fun to point this out. Wikipedia has 181 shootings worthy of articles, or 0.56 per million. Australia has 13, or 0.54 per million. As you've pointed out, Australia has a lower population, so this probably means that smaller shootings are worthy of articles. Removing shootings with less than 5 victims(which wouldn't have an article if they were American) gives us 7, or 0.30 per million.
Going back to homosexuals, the US has 148 items in Wikipedia's "History of violence against LGBT people in the United States", or 0.47 per million. Australia has 13 entries(and no dedicated page), or 0.54 per million. I'd almost surrender that point, if Australia didn't have 100% less cults walking around shouting that god hates fags, and 100%(or 6) less mass shootings of homosexuals.
Admittedly, I truncated all my numbers because I'm lazy. Sorry.
This amounts to putting words in my mouth. The only point I was making is that the stats you were citing were somewhat disingenuous in their framing. Your framing still comes across as poison pen material.
I'm not arguing that the US has it all figured out. I have plenty of criticisms of my own country. But this kind of venom essentially makes your words hypocritical. It amounts to decrying the hatred here while being hateful.
2) He's gone, and resigned to having fun on talkback radio.
3) Cloudy today, but it's being shut down.
2) gone for now, still talking, still reflecting a roughly mainstream sentiment of bigotry which largely defines Australia.
3) Yeah, same with us and Guantanamo... get back to me when it’s actually closed and the lots of the detainees improve.
And that's not even thinking about the possibility of unintended side reactions that create toxic products. Do a google search for "MPTP" if you want to read about amateur synthesis. A ton of people ended up with Parkinson's disease due to a bad synthesis.
That said, if your IR looked just like the real IR, you have strong evidence that the drug you want is in there.
In addition, chemists are not just trained to “make stuff”—the average person isn’t trained to handle toxic chemicals. Even if a person is aware of how to handle chemicals properly, accidents really do happen.
A good example is that bromoethane is listed as a starting material for Daraprim on this website—Google for the MSDS for this chemical and you will know what I mean.
Then there are the clean up and analyses after you have made something. No, it’s not as simple as checking melting points.
I appreciate that people try to take it into the hands to fight what I personally consider to be unfair, but I think this is not how it’s done and it’s a terrible idea.
The reason I'm bringing him up is that he synthesised Daraprim (pyrimethamine) from domestically-available materials over a period of ~2 years.
There's an NMR spectrum at about 12:08 in the last video in the playlist, which shows that he doesn't quite have medical-grade Daraprim, and that he'd need a lot of purification to get there.
How do sites like this seemingly thrive (Goop!) when doing something really conservative like talking about food chemistry and germ control is such insane drama? I just don't get it.
(I have a form of cystic fibrosis and have spent a lot of years getting stronger and healthier using primarily dietary and lifestyle changes. I used to be really open about that, which was nothing but an ugly shit show every step of the way.
I am probably making a huge mistake to comment on that. There seems to be zero path forward for me. I genuinely don't understand it.)
Or look at Medicaid. It has 50 payers (or more, not sure how territories are implemented). ~1/4 of Americans get health coverage through Medicaid.
I'd rather go that route than start a lab in my garage.
"Millions of adults skip medications due to their high cost
Howard LeWine, M.D."
"Almost 1 in 10 Americans Can't Afford Medications Says CDC"
"Most Say They Can Afford Their Prescription Drugs, But One in Four Say Paying is Difficult, Including More Than Four in Ten People Who are Sick"
"Even the Insured Often Can't Afford Their Medical Bills"
One for the "never thought I would actually have to say this" list.
Why do you think that first group doesn't matter?
You're hunting for cases where a person with an acute condition fell down and died on the spot because money-grubbing doctors callously refused to give them medicine. That doesn't usually happen in the US, because hospitals are required to administer emergency care without advance payment. That doesn't help the tens of thousands of people who have to choose between getting a checkup and paying the rent, or the checkup doc refers them to a specialist that costs $10,000, or they feel shitty after an accident but they know the bill for the emergency room visit will bankrupt them; so they gamble that it'll get better on its own, and by the time it's clear that it won't, it's too late for emergency care to save them.
...Did you read that article you linked to? It outright says "I do think medical bills contribute to or cause a significant number of bankruptcies."
“Homemade, handmade pharmaceuticals”.
Could a random person do a 5 step synthesis using specialized reagents? No.
Do it wrong, and a child dies...