I used to use Firebug exclusively, but since developing a WebKit oriented web app, I had to use the web inspector. At first I hated it, but after I got used to it, I never go back to Firebug.
It's too bad that Firebug keeps stagnating/backsliding, introducing bugs from version to version but not really improving the development experience much. (I have some friends who stick to Firefox 2 or even 1.5, because Firebug there works better in some ways than the more recent versions)
It's nice that the webkit inspector is picking up the slack, but it'd be even nicer if someone had the time/resources to sink serious development into firebug and keep both of these tools advancing.
I'm genuinely excited by this. This is a great chunk of really valuable enhancements, particularly those surrounding inspecting Ajax requests and the debugging -- I make heavy use of both.
Previously I've had to revert to Firebug for specific features -- like seeing formatted JSON -- but I think that's behind me now. Yay!