I haven't tried, but life is better if you don't minify on save. I assume you're using Grunt or Gulp; make a "build" task and use that for minifying. Your preprocessing time will go down, and that means getting your changes into the browser faster. Feels better than having to pause before hitting refresh, or worse, having to refresh twice.
Yes, using Gulp. Do you have a release script which does the final build on deployment? How does that work exactly? Don't you need to have a specific markup just for production then?
Yep, "gulp" watches and recompiles my stylesheets, and "gulp build" minifies stylesheets and scripts. I don't need to use different markup[0] since my stylesheets are all one file by default (Sass/LESS imports vs manual concatenation), and I use wreq for script loading.
[0] Actually, that's not 100% true - I read from an environment variable server-side and if it's in dev mode, I render the LiveReload script tag. Actual assets remain the same though.
