Nightlife isn't concentrated into small eras because of licensing. If you want bars and nightclubs spread out through an area, you are arguing for liquor licensing.
In neither the Vancouver example nor the Wrigleyville example is the problem "college students".
1) Nightlife and fun weren't utterly concentrated into single small districts, forcing people to commute to go out for an evening.
2) Cities and towns dealt civilly with college students instead of treating them as pinatas.