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> Have you considered that there may be permanent changes to your brain, that you're not able to perceive, similar to the radical shift in personality we've observed in Elon Musk?

I think people undergo permanent changes to their brain that they can't perceive, all the time. Hacker News and other social media definitely change your brain. So does having more wealth than you can conceivably spend in lifetime. I suspect the latter is more directly responsible for Elon Musk's trash personality than microdosing.

While I am a strong advocate for legalizing hallucinogens and empathogens, and am certain there are clinical uses for at least some of them which we are in the early days of understanding, I'm not as convinced by the science on microdosing (which specifically refers to sub-perceptual doses). But with so many people who seem to benefit from it, I support people who find it helpful doing so, even if it's just placebo effect.




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