That's what the theory says, but my experience disagrees. I find that when the remote workers have to be kept in the loop or the work doesn't get done/get done properly, then managers make sure they are always up to date.
I've not found that to be true in my career. Where remote work is the exception, rather than the rule, the remote employees are frequently in the dark, and often simply fail to work out. Managers can only do so much when you're missing the critical water cooler/hallway/impromptu meetings.
I've worked in remote-only environments, and (effectively) local-only, both of which worked pretty well. Local-first/remote-rarely hasn't worked.
I've not worked in anything close to 50-50, though, so perhaps that has a better shot at succeeding.
> missing the critical water cooler/hallway/impromptu meetings
Maybe that's the crux of it. I've never worked in an environment where things like that amounted to much. If one of those meetings started to become important, it would always end up with "let's find a meeting room and include Charlie and Susan and get this hashed out."
I'd go so far as to say that if that's the way a team is primarily communicating, there is something structurally wrong.