I had a doctor tell me to take that dose for at least a few months a few years ago after low levels in my bloodwork during the winter. But I've never known if I should lower the dose to take on a continuing basis or adjust during the summer when I get a little more sun (but I still work in an office/at home so spend a lot of time indoors, especially now).
Specifically, Vitamin K:
Ballegooijen, Adriana J. van, Stefan Pilz, Andreas Tomaschitz, Martin R. Grübler, and Nicolas Verheyen. “The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review.” International Journal of Endocrinology 2017 (2017). https://doi.org/10.1155/2017/7454376.
Uwitonze, Anne Marie, and Mohammed S. Razzaque. “Role of Magnesium in Vitamin D Activation and Function.” The Journal of the American Osteopathic Association 118, no. 3 (March 1, 2018): 181–89. https://doi.org/10.7556/jaoa.2018.037.
I'm also curious on your thoughts on what you consider high for supplementation, vs say sunlight exposure, as a single MED of sunlight exposure is equivalent to about 10-25K IU of oral supplementation.
Engelsen, Ola. “The Relationship between Ultraviolet Radiation Exposure and Vitamin D Status.” Nutrients 2, no. 5 (May 4, 2010): 482–95. https://doi.org/10.3390/nu2050482.
On the flip side, I've seen that in a recent RCT, that recommended sun exposure guidelines were not sufficient in reversing deficiency:
Lee, Yu-Mi, Se-A Kim, and Duk-Hee Lee. “Can Current Recommendations on Sun Exposure Sufficiently Increase Serum Vitamin D Level?: One-Month Randomized Clinical Trial.” Journal of Korean Medical Science 35, no. 8 (January 22, 2020). https://doi.org/10.3346/jkms.2020.35.e50.
What are your thoughts on the research about low Vit D being caused by inflammation as opposed to the reverse?
Also any thoughts on what form of testing works? Seems like many things tested often have variations that are not routinely tested for.
My autoimmune disorder was initially diagnosed via positive responses to antibiotics.
Normal testing confirmed it later on, so I’ve been highly interested in some of these unusual approaches.
result: 13.3 ng/ml, normal range: 25.0 - 80.0 ng/ml
I'm taking Vitamin D3 Max 125MCG per day, is this "overdose"?
Study confirms vitamin D protects against colds and flu
If you're getting 105% of your magnesium from these items, then you're also getting 105% of your Vitamin D before taking any additional Vitamin D supplements/sun exposure.
Adding the 5000IU of Vitamin D3 would be increasing your intake to 5840IU (730% of DRV) - assuming you didn't ingest anything else fortified with Vitamin D.
Finally, do you see much difference in getting to that high blood level of vitamin D from sun exposure vs D in diet (fish, etc) vs supplements?
I recently started trying to get more vitamin D from the sun, a sperti vitamin d lamp, and food, in order to reduce the amount of pills needed for a given IU. I use the dminder app to track estimated blood levels between tests.
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Is it really possible to have enough vitamin d exposure just from diet for someone who lives in a northern state which doesn’t get nearly as many sunny days as a place like florida or california?
I've tried searching the internet before about Vitamin D and it's surprisingly confusing, both about dosage as about intake routine. Also confusing that daily requirements are contested to be way off to our real needs, it's just a lot of misinformation lingering around that I, as a layman, can't really parse it.
There is plenty of magnesium in foods.
Men are recommended a bit over 400 mg magnesium per day.
Black beans are quite rich in magnesium, but you still need to eat more than 3.5 cups of it to get the recommended daily amount of magnesium, or 5 cups of cooked brown rice, spinach? That's 2.5 cups of boiled spinach.
Generally, if you eat between 5-10 cups of solid food each day, you are fine no matter what you eat. But that's a lot of food unless you have a very physically active, job.
It used to be mostly true, when most people had physically demanding jobs, it's not true any more.
"National Health and Nutrition Examination Survey (NHANES) of 2013-2016 found that 48% of Americans of all ages ingest less magnesium from food and beverages than their respective EARs; "
No affiliation, not a doctor, etc., just thought this particular essay was well stated.
Thanks for coming here to share your expertise!
The answer is a loss of calcium, so high level found in urine test: if you had way too much vitamin D, then you would start releasing the calcium from your bones.
I don't think that taking calcium supplements would help, because calcium metabolism (https://en.wikipedia.org/wiki/Calcium_metabolism) is much more complex than that.
If you need more information, please ask away.
Last time, i tried 5000IU, but this came after weeks of not taking any D supplement, and I've not taken any since. My reasoning is: that would effectively make the average dose < 400 IU, so shouldn't give me any problems, yet it does. Maybe I'm getting more from the sun than i realize :/
I'm a special case. Trying to explain that is probably a can of worms.
shouldn't give me any problems, yet it does
There may be other factors there, which I could potentially speculate on. But A. It tends to be a can of worms when I start speculating like that and B. You didn't initially give enough info to really warrant such speculation. You only gave enough to make me feel like the safe bet was to comment on the dosage and leave it at that.
A good number of months in and I start getting all of the symptoms - lethargy, constipation, stomach and intestinal pain, urinating very frequently and feeling like I had a kidney infection.
Bloods came back all normal, including vitamin D and calcium. My symptoms chime so much with Vitaminosis D (Vitamin D toxicity) that I wonder whether the serum levels are accurate indicators of such toxicity. Vitamin D is stored in fat and the calcium gets deposited in muscles - two possible mechanisms for this.
However, I do not know for sure. Either way I have been scared sh!tless of self-prescribing anything else. No matter how mundane it seems.
If your wife wants to write a blog post on the subject, I'm sure there'd be a lot of interest.
> there is virtually no risk of toxicity in supplementing up to 10,000 IU of vitamin D3 daily
No one who talks about supplementation seems to think a level of 8000 over a long period is necessary to obtain adequate levels.
I think by the same token the recommended supplement level of 600 IU is inadequate to reach a sufficient level. But the paper in question didn’t test their result empirically.
explicitly point out that each vitamin D supplementation must be accompanied by
sufficient vitamin K2. This certainly prevents the rise of the calcium level in the blood,
which is often seen as a risk for the supply of vitamin D
People recommend really quite doses: K2-MK7 at 100 to 200mcg, or alternatively K2-MK4 15 to 45 mg (not mcg).
Presumably people on those kind of doses are taking it under medical supervision, or are idiots/under the control of idiots.
I am not a doctor, but without further information it seems that as ever, following the guidance on legit supplies specifically and mainstream medical advice generally is a good rule of thumb.