The Psychedelic Salon podcast did a long reading of Pickard's novel, The Rose of Paraselsus, which included an introduction which went in to Pickard's background.
It's well worth listening to.
The first episode of the series can be heard here: [1],[2]
Thanks for the link. Haven't listen to that podcast in many years, but am excited for this. It's funny that his style of thinking and writing is clearly kind of similar to Nick Sand, if you've listened to the previous episodes with him.
This is delightful news. I really hope in the coming decades the research of organizations like MAPS get more attention and become completely mainstream.
Making psychedelics Schedule 1 set us back decades that could have been spent doing important research on a large number of mental health conditions.
MAPS (multidisciplinary association of psychedelic studies) is systematically demonstrating the positive effects of psychedelics.
Their most impressive work is in PTSD. In Phase 2 trials, they took people with established PTSD (for years) and undertook ~3 guided psychotherapy sessions with MDMA. Within 2 months, 53% no longer met criteria for PTSD and at 12 months 68% didn't.
Far more efficacious that anything else we have. Powerful tool for psychologic healing.
For those that want LSD but not have to be a criminal I recommend trying 1-P LSD which has the functional class of LSD without being illegal in most countries, happy tripping. If you're on the wall about trying it micro dose and work your way up to something functional.
In the UK we had an act introduced to combat legal highs by making essentially everything illegal and then legalising products, rather than trying to ban legal highs as they were discovered.
Despite this 1P-LSD is still being sold in the UK in a supposedly legal way. It's sold as micro dosing pills that are low enough dose to not produce any psychedelic effects if you just take one. There's nothing stopping you from taking 10, though.
(I have no idea if this supposed workaround would actually be seen as legal if taken to court, but the company has been active and selling in the UK for over a year now, they are a sister company of the well known lizardlabs)
Is LSD schedule I in the US? If so it might be prosecutable under the federal analogue act, although whether that act matters seems to be somewhat debated.
I know some other countries have blanket bans on RCs and analogues as well.
Yes. Most psychedelics are Schedule I. Though to be fair, that's in large part due to the UN Convention on Psychotropic Substances, of which only 11 UN member states are not party.
Very close / the same in my experience. I've never had the exact same effect even from two doses of LSD from the same sheet, much less different producers, but 1p-lsd was just fine and felt the same to me.
I bought a bit before it was put on the controlled substances list in my country. A good demonstration that legal LSD doesn't end the world: it was legal, it was LSD, the world didn't end!
>I've never had the exact same effect even from two doses of LSD from the same sheet...
As a retired neurosurgical anesthesiologist (38 years) who has never taken LSD or any psychedelic/psychoactive substance, I found your observation very thought provoking.
More likely than not, the LSD on each unit on a given sheet is chemically identical.
Therefore, the only variables are 1) the amounts in each dose, and 2) the substrate on which the drug will act (i.e., your brain at a given instant is — on the whole — the same, but functionally totally different from second to second as pathways activate and connect).
I would therefore hypothesize that, more likely than not, most if not all individuals who have a strong response to a given dose of LSD will have different responses to repeated doses from the same sheet.
I'm hoping people who've taken LSD will school me.
I think it's important to differentiate between the effect of LSD and the experience of the subject. The effect is always the same (for the same dose) but the experience is different. The differences in experience come because LSD is just a modifier on your perception and thoughts. Thus you can only have the same experience if you repeat the same sensory inputs and thoughts - which is pretty much impossible.
LSD has quite a bit of subjective experience change based solely on mood, set, and settings. Although beyond that, everyone's reality is not the same as the next guy. Aside from that, repeated dosing of anything at all can be different from dose to dose based on body chemistry, tolerance, hormone balance, and dopamine/adrenaline type of responses. Mood plays a large factor in this as well. Tylenol does not work the same way at the same dose in each and every person, either.
I tried ETH AL and 1p half a month apart , they all been a lot of different
AL lad 150ug was happy ish almost no visuals, very slight mind changes
ETH lad 75ug played most with my mind visuals were weak but very distinct to lsd, touch was amazing,but was extremely easy to get afraid of smth(thought loops etc)
1p lsd 125ug was just like lsd with maybe more vasoconstriction atleast hands felt colder n hikes were more exhausting than lsd
According to the testimony of Brandon Green (the victim), Cole actively participated in his torture and mutilation alongside Skinner, she apparently even paid Green's rent in advance so nobody would look too hard for him. The case is really fucked up: https://caselaw.findlaw.com/ok-court-of-criminal-appeals/125...
She got off basically scot-free (she's on youtube and IG) because she most likely snitched, and it probably helped that she was a young white woman.
Not that Skinner doesn't deserve everything bad that could happen to him, he was the main torturer of Green, and a DEA informant and the reason Pickard got caught, and got life.
It describes a drugging, kidnapping alongside a torture, in part arising out of a love triangle and a clanenstine drug lab in an ex-Military middle silo.
I urge you to look into Krystle's story more. She's an absolutely vile person who participated in the torture and attempted murder of her boyfriend, Brandon Green.
The Caselaw link posted by masklinn provides a legal summary of the kidnapping and torture of Green by Skinner and Cole.
However, in contrast, I found the This Land article "Subterranean Psychonaut" by Mason, Sandel, and Chapman to be a fascinating and in-depth read. It's replete with endnotes and provides information about Cole's actions after the police picked up Green.
People like the DEA and the FBI can just make up statistics to make themselves look good and they're reported as fact. The drugs seized had a street value of N million dollars, the supply of LSD went down 95% after his arrest. Good job DEA
For some reasons the feds in the 90s were unusually interested in prosecuting psychedelics. I'm of the opinion that all drugs should be legal, but even if I wasn't, I think I would still question why LSD manufacturers were getting such long sentences around that time. Never really made sense to me.
Having no experience with it, nonetheless, the popular impression of LSD is that an incredibly small amount of it can be on something and inadvertently ingested, so I can see the perspective that making, having, or dealing it is an unacceptable risk of harm to people who didn't consent.
Counterpoint: PFOA / PFAS long chain polymers even at extremely low levels act as endocrine disruptors. DuPont leaks this stuff at its plants, people living near by have elevated types of specific cancers, and nothing is done.
If you can get 20 years for two sheets of LSD, I’d expect life in prison for everyone at the companies who continue to leak this toxic stuff, and full payment of affected people:s medical bills, for starters.
It doesn’t happen because LSD can be used recreationally, “drugs are bad,” and PFAS is only used by well-respected businesses.
Presumably they aren't dumping beyond the legal limits. That's how our system works. The EPA or other agencies attempt to determine what's safe, the government makes some regulations, and if you follow those regulations, you don't go to prison. Even if the regulations are bad.
> "Presumably they aren't dumping beyond the legal limits. That's how our system works."
They have and probably still do though[1]. Lived only a couple hours from the location of the film and my wife grew up in a city on the Ohio River they were dumping chemicals into. Was in the local paper here almost weekly during the late 90s and early 00s.
Sure, only because the chemicals weren't regulated yet by the government (and they fought as hard as they could to keep that from happening). Funny enough, DuPont actually had its own regulations for dumping such chemicals and knowingly violated them (which became the cornerstone for the class action lawsuits against them).
That said, there's plenty of cases of illegal dumping out there with chemicals that are regulated.
In addition to a regulation’s existence, EPA must also do the testing and prosecute violations. I’m not sure they do here, even before the trump era, especially since for a while EPA was steadily lowering the safe limits. I think instances of that are contained within those articles, but unfortunately they are walls of text and you and I have no reason to greatly trust my memory.
My post was in response to this question:
> I can see the perspective that making, having, or dealing [LSD] is an unacceptable risk of harm to people who didn't consent. Is there some reason that's unrealistic?
My point was that the factors of “unacceptable risk” in regulations are laden with things that have nothing to do with actual levels of harm to people. You corroborated that point with your post; I’m only clarifying here. This is the system we have, and it can be quite bad at actual harm reduction due to cultural factors.
It’s weird to live in a world where a substance that showed great promise in therapy, fighting alcoholism and other addictions etc. has been banned for 50 years, while another substance that makes dish washing and floor cleaning easier but causes cancer and birth defects in people close to where it’s made is broadly sanctioned.
It is an unacceptable risk for people who didn’t consent, but that’s a different matter. We should punish people who give others dangerous things without consent.
Well, you can get into trouble if you start playing around with radioactive material, too. I think "The Radioactive Boy Scout" has been mentioned on HN a few times.
I think a reason why dangerous things are regulated is because even though they don't always lead to harm, the harm can be grave and impossible to undo. Even if an unexpected trip doesn't technically lead to permanent brain damage, if the behavior were misinterpreted (for instance as a psychotic episode) it could permanently wreck a person's life.
As long as you think the same arguments apply to toilet bowl cleaners, oven cleaners, windshield washer fluid, tylenol/paracetamol, antifreeze and visine, this makes sense.
> That's not to say all hazards are equal or all substances need identical regulations.
This is a non informative answer. Let's talk numbers, is 20 years a reasonable time to be incarcerated for a sheet of LSD? How many years is appropriate for a pack's worth of hand smoke, then? How about carbon monoxide from driving year round?
I think there's no reason there should be a single person on both sides of the equation, never mind arbitrary choices of the harm scenario. In a contrived utilitarian scenario, you could save 1,000 people and send one to prison, or vice versa.
Apparently it's dead comment time, yay! But yes, some things are dangerous. LSD is less dangerous than many many legal things, such as guns, alcohol, driving, etc, so why is it illegal?
I read Stephen King's Firestarter at an early age, so that, and other things influenced by MKULTRA, factors in to why I think LSD is scary.
The other issue I have is that when people say that LSD can harm people with a predisposition to schizophrenia or whatever, it's frightening because it seems like a stereotyped thinking pattern that's useful for denying unacceptable causal hypotheses that might in fact be real.
I don't have a counterexample, as the allegations I was reading on Wikipedia are generally of intentionally drugging people,[1][2] but I wouldn't be particularly confident in your statement; how would one know it hasn't happened?
Yes. At any gathering of a certain type that’s large enough, like a music festival, you run the risk of eating or drinking something that’s been spiked with something. Most people who do so try to be up front about the “bonus content,” but because of legality they will often couch it in lingo like “space brownies” and the like. If you don’t know what that means, you could be in for a wild ride without anyone having ill intentions.
People playing around with radioactive stuff, even if they are well-intentioned, can easily mess up and contaminate themselves and others with it. Radioactivity is not detectable to any of our senses, only radiation poisoning is. Things are completely different with LSD and other drugs. You could argue that making meth is a dangerous activity in itself, but a properly regulated industry could evaporate any real need to home-brew large amounts.
Ah the whataboutism is strong here. The point is, life is inherently dangerous. We make laws to punish people for making it more dangerous. People have had massive overdoses of LSD [see Wikipedia entry for LSD], several thousand times the standard party dose, and gone on to lead normal lives. All the arguments you make are exactly the same as arguments against alcohol, but LSD is actually much safer.
By what mechanism will people who didn't consent come into contact with LSD? As residue accidentally transferred by physical contact? By that logic peanuts and other tree nuts should be illegal because trances of its oils can kill those who are sensitive, unlike LSD which is pharmacologically safe. Additionally, while there are many examples of trace residues of tree nuts triggering anaphylactic shock in those not directly handling the nuts, I haven't heard of a single person accidentally ingesting LSD that wasn't willfully handling the drug (which implies consent to any accidental ingestion in my book).
A friend of mine was dosed without her knowledge or consent at a festival. She thinks it was from a cup of punch she was given, input to this day can’t be sure of the route of ingestion. She was familiar with LSD and realized what was happening, but was not prepared for it and had a rough time.
It’s completely irresponsible to give someone a drug without consent, outside of some forms of medical intervention, regardless of your intentions.
Well, we don’t do much to regulate the most common date rape drug, Alcohol, so it’s not clear why we need to do so much to prevent adults from consensually taking it.
Taking drugs and potentially becoming addicted has societal externalities. We currently have a opioid overdose epidemic in the US which taxes the emergency response system, not to mention the pain it causes to friends and family. There's a reason opiods are regulated in the medical industry (some would say too little).
LSD and opioids are very very different things, and a major driver of the opioid epidemic is certain companies in the pharmaceutical industry legally pushing it.
IMHO if alcohol and nicotine are legal, then anything "soft" that is not particularly addictive should be legal. It's fundamentally unjust to lock people up for using or having substances that are for the most part less dangerous than entirely legal and socially acceptable substances.
Alcohol is actually kind of nasty stuff if you look at the real statistics, especially if used in excess.
I'm not claiming LSD is absolutely harmless, just that it's not physically addictive at all and not nearly harmful enough to merit the harsh criminalization and heavy sentences it receives. LSD can be safe and rather interesting if used occasionally but heavy use or use by people with pre-existing psychotic tendencies can be psychologically dangerous.
My personal opinion is that drugs like LSD should be subject to some kind of licensing regime similar to other hazardous activities like driving a car, flying a plane, or owning and using firearms (in some states). I would also be in favor of blanket bans or at least heavy restrictions on any advertising for drugs, including alcohol, nicotine, and pharmaceuticals.
>My personal opinion is that drugs like LSD should be subject to some kind of licensing regime similar to other hazardous activities like driving a car, flying a plane, or owning and using firearms (in some states).
I disagree. Driving a car or flying a plane can directly harm others, so the licensing process makes sense. Consuming LSD though? It doesn't directly harm others when I consume it.
LSD is not associated with major organized crime groups like cartels. It tends to be manufactured domestically in the Pacific Northwest and in semi-rural locations across the US.
The only reason such an inhumane black market can exist is because no one is allowed to produce it legally. I would argue regulators are responsible for the harm caused by the trade.
No, you have your logic backwards. The conclusion that with lax drug laws, there'd be less violence associated with drug manufacturing and selling is correct. But the laws don't cause the violence, they make it so violent individuals are the only one's willing to fill the supply.
If I outlaw [drug], I'm not responsible because you kill someone trying to sell [drug].
I disagree. If you take [action], and it was a necessary and sufficient condition for [consequence], then you are morally responsible for that consequence. (Sure, the individuals committing crimes in this concrete case are also morally respoinsible). In this case, I think it is correct to say that the laws cause violence, since that violence would not be happening otherwise.
There is a common trope that criminals sit down and decide what crime they will commit, and decide that drug dealing is the best one. In fact, that is backwards; if the TAM of crime is cut by 10x, then there are fewer jobs, and at the margin some will stop. And in the other direction, if there is no longer easy money to be made by selling drugs, then fewer would find their way into the drug business in the first place.
See prohibition in the USA for a natural experiment that supports my claims here.
> I disagree. If you take [action], and it was a necessary and sufficient condition for [consequence],
That's exactly the thing though isn't it. Marijuana is (was) illegal, and has VERY LITTLE amount of violent crime related with its market. Making something illegal isn't enough to induce violence alone. So the [action] of (making drugs illegal) itself alone isn't enough to make [consequence] of (additional violence) to be a certainty.
Or, consider the simple case. I insult you, you punch me. You clearly wouldn't have punched me if I didn't insult you. Who's at fault here?
Actually, substantial cartel activity was associated with marijuana, with significant violence associated with production in Sinaloa and transport into the US. It was a huge fraction of cartel activity, both in volume and dollar value.
The main reason cartels didn't take over entirely was A) there are few effective barriers to production, B) the low density of the product favors domestic supply, and C) making high quality product is time consuming and logistically complicated.
And there is still violence associated with marijuana in CA because about 80% of the market is still underground due to the extreme difficulty of navigating the current regulations.
Everyone responding here shared a similar opinion regarding the idea of laws being responsible for the violence, so let me share another problem where the laws play a role, namely legal dangerous fake substitutes. Take for instance 25I-NBOMe. https://en.wikipedia.org/wiki/25I-NBOMe#Legal_status It remained (has remained?) legal in many places for more than a decade.
Yeah, "designer drugs" -- the products of someone trying to make a drug that works on the same systems but is different enough in structure from anything on a Controlled Substances list are bad news. The problem lies in the fact that many drugs with long histories of human use (opium, marijuana) have long histories of human use, and so they've been tested extensively and are known not to produce horrid adverse effects. They might not be the global maximum of safety and efficacy, but they sure are likely to be close to it. Trying to replicate a compound that has been tested for efficacy and safety for decades to millenia (and not being allowed to just change tiny things on the molecule) is not something that is likely to give results close to the original. Other examples of that include synthetic cannabinoids (https://en.wikipedia.org/wiki/Synthetic_cannabinoids#Toxicit...), which are a lot more dangerous than actual marijuana. i'm not claiming marijuana is harmless, just, like, synthetic cannabinoids really are just that bad.
Ironically, the obverse task -- trying to create a molecule that acts on similar neurobiological targets as an illegal drug but doesnt get people "high" or look like a molecule from an illegal drug -- can be similarly fraught. The flagrant example is BIA 10-2474, an experimental drug meant to target the endocannabinoid system in a roundabout way: not by directly activating receptors, but by inhibiting an enzyme that degrades the endogenous chemicals that activate endocannabinoid receptors, which would, ideally, have similar effects as directly activating those receptors. A trial of it killed one person and irreversibly and severely neurologically damaged a few others. This isn't to claim that FAAH inhibition is doomed to failure, just that safely messing around with sublimely complex neurochemistry is difficult; adding constraints like "must not make people feel high" or "must not look like Prohibited Molecules" makes it needlessly harder.
I understand where you're coming from, but it doesn't seem so clear cut to me.
Let's say:
I have a choice to outlaw drug X or not. I can infer with near certainty that this policy will lead to a black market run by violence that gets people killed. Nevertheless, I outlaw drug X. People get killed.
What responsibility do I bear?
I honestly don't know, but neither "none" nor "100%" sounds right to me.
It's not clear cut, but the metrics chosen are important. If you care about drug use more than violence, it does seem to be clear cut. Same for the inverse.
You bear no responsibility. Everyone must take responsibility for their own actions.
I have a kid, I raise him to the best of my ability, and commit no egregious mistakes. He grows up and murders someone. Am I at fault? Obviously not, just because I'm a part of the equation, doesn't mean I also should be assigned blame. If I didn't have a kid, [person] would still be alive. That doesn't mean I'm responsible.
That parents' behavior has no effect on their children is not a universal belief. I think that a belief that one bears no blame for what one's children do is a way to inevitably raise terrible children. That's like not having any responsibility for whether the product you built works, or is toxic.
edit: blame isn't exclusive; everybody can have 100% of it. Although IMO blaming children for what they've done (however you define the age of majority) is almost entirely scapegoating. You might as well convict a dog or a pig as an adult if you would convict a 13 year old.
That isn't the same. After you raised your kid you don't control their environment. Does an environment contribute to individuals actions? Consider the thin blue line. Populations under duress and their cooperation with authorities.
> But the laws don't cause the violence, they make it so violent individuals are the only one's willing to fill the supply.
This is untrue. The vast majority of the US drug trade is done without violence.
There’s violence in the powder/pill drug game because the profit margins are so high, creating an immense amount of competition. Sometimes you can 5-10x your money off powder, that isn’t really possible with marijuana or lsd, unless you are the grower or chemist.
There’s very little violence in the marijuana and hallucinogen markets.
You're correct, I was speaking somewhat abstractly, and only meant to include the smaller subset of the drug market that has a large amount of violence associated with it.
> But the laws don't cause the violence, they make it so violent individuals are the only one's willing to fill the supply.
The laws prevent relying of the police in protecting your business with violence. The law creates jobs where violent people excel but those same violent people would not necessarily be violent without it, they may also be really good pianists, it just doesn't pay as well.
If you pass that law knowing full well that it will create a violent black market, you certainly are responsible when it does.
> The laws prevent relying of the police in protecting your business with violence. The law creates jobs where violent people excel but those same violent people would not necessarily be violent without it, they may also be really good pianists, it just doesn't pay as well.
100% agreed.
> If you pass that law knowing full well that it will create a violent black market, you certainly are responsible when it does.
I'm not sure you could say knowing full well. At least not when the laws were enacted. And knowing that it could create a black market, isn't the same.
Also, if your calculations also lead you to believe that you could control the market, keeping the violence to a small minimum. You're at worst responsible for a small mistake in calculation. Not the violence that you were unable to predict.
The argument of who's to blame currently is the people with access to all the information who still refuse to act.
At the time of beginning the war on drugs, there was already examples to take from prohibition.
This calculation seems negligent. Like, I could shoot you in the face, and it wouldnt be my responsibility if you died. I could only know that it's a possibility that you could die, not that you would definitely die
I disagree as well. The violence is an unintended consequence, but it's also a known consequence, and has to be taken into account. You can't separate the good and bad consequences of a decision and wave off the negative ones because they manifest themselves indirectly.
Let's not pretend that "outlaw [drug]" doesn't mean "threaten to harm or kill people distributing [drug]." If you sanitize it into an abstraction, it intentionally conceals who is starting the cycle of violence.
The laws don’t directly cause the violence, by they do create an environment in which violence is more likely (or violence around drug manufacture and trade).
Absolutely. Violence related to drug dealing is a result on the insane profit margins on heroin, cocaine, and meth. It’s possible to make 70-90% net profit on cocaine if you can get it at wholesale, which is nuts. Of course people will kill each other for the chance to make 90 cents on the dollar.
If you bought some Chinese fentanyl and made “heroin” I bet it’s closer to 95-99% net, imagine having a money machine that spit out 20 dollars for every dollar you put in. No wonder people kill each other over drugs.
> Of course people will kill each other for the chance to make 90 cents on the dollar.
I was going to argue with you. Something something... not everyone is that bad. But then I considered all the harm large corporations do... Shit man wtf is wrong with humans?
Our moral reasoning is so jammed full of the remnants of imperial dogma that we cannot make a coherent moral argument to one another that resonates beyond self interest.
We end up with a world where normal human behavior is stigmatized, and once that happens there’s no meaningful way to actually discuss what should be stigmatized.
I almost added a section about how corporations have killed (United Fruit, Congo Free State, and others) and would kill for those margins if the activity was profitable to offset the repercussions from killing, but left it out. I’m glad you noticed the similarity without it being explicitly mentioned.
> Funding criminals and terrorists is surely worthy of punishment, do you not agree?
Greater society does. Unless, or course, those criminals and terrorists are the wealthy leadership of large private businesses and the crimes are committed either overseas upon marginalized people, or over a long enough timescale so as to be virtually "unprovable".
It's a lot harder to write a coherent response than downvote, but given there's so much misinformation around the internet, you could do nothing but try to correct it by replying, 24/7 and still get nowhere. Downvoting hides bad comments, and depending on your metrics comments that are based on a flawed premise should be hidden.
Buying drugs do not meaningfully fund terrorism. So to criminally prosecute someone for buying drugs because it might stop them from giving money to the "bad guys" is an abuse of both humans and logic. The bad guys only sell drugs because they're the only ones willing to break the law. If you cared about stopping them, you legalize recreational use so non-criminals would make the money. But the whole argument for prosecuting individual users is because "drugs are bad and you're bad for using them". The whole drugs fund terrorism was it interesting lie or propaganda, (depending on your view). And lies even when repeated unintentionally or unknowingly should be downvoted.
Speaking to this point exactly; drugs do not meaningfully fund terrorism. In a person's locality, one can readily learn what their supply chains consist of, and who is the chemist/grower producing it. For one to assume flat out that all drugs somehow for some reason pass through a cartel shows lack of knowledge, or bad faith. Especially today in the booming drug market, one can very easily buy right from cannabis growers and right from chemists, or nearly directly. Cartel drugs are frankly poor quality absolute garbage.
OP mentioned terrorism clearly as an after thought. The bulk of their message was focused on crime. This gives your position a sort of "knee jerk" air about it. To then be given a low effort downvote option to facilitate your low effort analysis simply enables your perpetuation of a reactive culture.
And you're not one person against the world. You don't need to correct every single misinformed opinion on the entire internet 24/7. Take the time to help one person who you feel is misinformed and bring them to truth.
But OP did their argument a huge disservice. Even considering I wasn't focused on that aspect given I specifically chose "bad guys" instead of terrorists. Or that their concept that drugs are necessarily connected with crime. Their argument with or without adding in terrorism is based upon a either a lie or a misunderstanding. One that would wrongly have additional credibility seeming to be true if it got up voted.
But I'm curious to why you're blaming me (rhetorically) for perpetuating a reactive culture when not only am I not even sure what that means, but I didn't even downvote him.
And I appreciated your reply and considered your reasoning. It was a helpful observation that has tempered my distaste for downvoting.
Being HN, this is a good place to throw up some citations and they would stand a far higher chance of being read and understood by your target audience even if they disagree with you.
And I don't feel I'm "blaming" you per se, but your response gives the impression that even if you didn't downvote this specific referenced post, you've done it before for the reasons you gave.
In any case, I must have heard the same lies or misunderstandings because I thought the connection between drugs and crime was fairly obvious. I would absolutely appreciate some citations.
Bingo. Plus, as it pertains to LSD itself, what he said was patently false. LSD has always been largely distributed among intellectual circles for decent low prices and among hippie circles. Real LSD is not meth, and it's not heroin. It wasn't and isn't trafficked by cartels. Maybe fake synthetic chemicals being sold as "acid," but not pure LSD-25. It was a perpetuated government War on Drugs (tm) myth.
No, what is actually funding those organizations would be the profits of the drugs they are selling. The law may be responsible for creating an environment that allows such groups to prosper, no argument there. But an unjust law doesn't make it morally permissible to work with violent criminal organizations.
In any case I think it is unreasonable to downvote someone who is arguing in good faith simply because you disagree with their premise.
> No, what is actually funding those organizations would be the profits of the drugs they are selling.
No, that's a nonsensical sentence. Profits are funding. What I said is correct: The law is what is actualizing the profits (or the funding). Without the law there would be no profits, no funding. Ergo, the law is causing the funds to happen. Profits are not self-caused. They don't just happen by themselves.
> But an unjust law doesn't make it morally permissible to work with violent criminal organizations.
Yes it does. Morals are subjective. I'm absolutely fine with it. These criminal organizations are far less violent and less criminal than my own government which I fund by paying taxes.
Furthermore, the vast majority of people buying illicit drugs are not buying directly from violent criminal organizations or even non-violent criminal organizations. They're buying from a friend who buys from a friend who buys from a friend who might buy from a criminal organization (who might be violent).
> In any case I think it is unreasonable to downvote someone who is arguing in good faith simply because you disagree with their premise.
You (and them) made poor arguments based on your ill-formed opinions and presented no evidence. You both deserve the downvotes.
It's downvoted partly because of the reasons other commenters have given and also because it shows ignorance about the drug market and about LSD specifically. Why participate in the discussion when you are not informed?
Since America isn't officially the world police, switching scope like this makes a bad comparison. There are plenty of reasons the US might interact with foreign countries in a way it wouldn't with internal domestic groups.
Except it's quite possible that the LSD supply chain had no violence associated with it, so it's pure conjecture biased by a "drugs are bad, m'kay?" attitude. Those apples are far from guaranteed to be poisoned.
I've seen the same argument about cannabis, and while some may come from cartels, much of it comes from indy growers and that supply chain is more than likely violence free.
As mentioned by another, the whole element of criminality is manufactured by the state and was designed from the start as a tool of oppression, not to "keep us safe".
I'm with you on that. I'm only trying to say that if you believe drugs are bad. I.e. if taking drugs is itself inherently immoral the logic is still sound. I don't believe the drugs are inherently immoral I do believe that fruit from The forbidden tree is poisoned.
So let's prosecute the people who are committing murders, human trafficking, and property crime, which are actually crimes. Possessing a psychedelic is not any of those things.
Not sure I’d agree with “harms noone.” I have taken LSD and easily walk in the middle of the road with no cause for concern. Imagine a child accidentally eating some of it, etc. Could be worse than a loaded gun.
I’m all for legalizing natural stuff (mushrooms, cannabis, even coca plants) but once chemists start concentrating things or turning them into droplets it becomes extremely dangerous.
For instance, mushrooms grow on poop (and taste like sh*t), coca leaves are probably bitter to the taste (and not agreeable). So not much incentive to accidentally eat them.
One tab—the whole sheet even—of LSD tasteless and odourless, even hard to detect.
My rebuttal is “alcohol”. That settles any safety related debate, let’s move on.
I’m dismissing “think of the children” and “equivalent to a tool designed to kill” (and that tool is completely legal in the US) lines as obvious trolls, I encourage anyone else rebutting to ignore that as well.
Edit: To dismiss your argument that you edited in about dosage size and accidental ingestion. If LSD was legal, manufacturers would want to prevent accidental ingestion and design an RoA that isn’t a tiny tab of LSD. Keeping it legal means it will remain as is now. You’re arguing for legalization and don’t even realize it.
Furthermore, a quick google search shows some academic papers from the 70s about children accidentally ingesting LSD, and a news report from 2016 where a child may have ingested LSD accidentally, but there’s very little evidence that it’s a problem.
I agree with all of what you’re saying, but the comment I reply to says it “harms noone.” I am saying it does harm people.
To be frank, I have taken a decent amount of LSD in teenage years and suffer permanent effects from it (all mental stuff like anxiety and paranoia). Granted some of it was probably made in someone’s garage (legal stuff could have some sort of standards). But still, LSD is dangerous and point being it has potential to make people do things without cause for concern, and cause damage to others. It also lasts easily 8-24 hours depending on dosage.
Another point: if LSD was legal, then it would be legal for a cult to use it in rituals and as a way to manipulate individuals. Think Charles Manson—that’s a lot more dangerous than run-of-the-mill narcotics.
> To be frank, I have taken a decent amount of LSD in teenage years and suffer permanent effects from it (all mental stuff like anxiety and paranoia).
What proof do you have that your anxiety and paranoia are caused by your teenage LSD intake? There are plenty of people who have issues with anxiety and paranoia that have never taken drugs.
Consider that 70-90% of schizophrenics are tobacco users, and most started young. This is an astounding rate of smoking for a population subgroup. Did tobacco use cause the schizophrenia or did schizophrenics seek out tobacco?
Plenty of cults operate without drugging their members with LSD, if it was effective I assume it would be more widespread considering mental, sexual, and physical abuse are illegal and used as tools by cult leaders to maintain the cult and its membership. See NXIVM for a recent example. Giving people LSD is far more benign than beating or raping them.
I had a bad trip and afterward I had anxiety. No anxiety before then.
I don’t have “Anxiety” requiring meds and such—the effects taper off over the years.
Believe me, I know the effects I felt and what it did to me—statistics and external “scientific proof” are not required.
Also, true there are many ways to manipulate people. It’s what you can make them do while they are on LSD that is scary. If you try LSD you will know what I mean—you could walk into a train without hesitation or fear. At least if the other methods are used to manipulate people their underlying emotions, hesitations, and consciousness is intact.
Again, I agree certain drugs should be legalized. And perhaps LSD can be therapeutic in a good way. But, it is also very dangerous stuff—more so than other drugs.
That is my opinion and not based on rigorous research. But I have done a lot of drugs in my day—and I can say if I went back in time I still would have done the natural stuff (mushrooms, cannabis) but never would touch the man-made chemicals.
So, you don’t have proof, you just happened to develop anxiety around the time you started taking LSD, which was as a teenager, a time of notable change.
> If you try LSD you will know what I mean—you could walk into a train without hesitation or fear.
I’ve done LSD a number of times, the most recent was 8 days ago. I’ve never lost the interest in self-preservation while tripping on LSD. You cannot control someone’s mind when they’re on LSD.
Please provide me with a drug that LSD is more dangerous than, keeping in mind that mind control with LSD isn’t possible. I’ve been a heroin addict and severe alcoholic, and I’ve also taken LSD a number of times. Being an addict/alcoholic is so much more dangerous and detrimental than any use of LSD than I find it hard to take you seriously when you make such claims.
Replace LSD in your argument with "alcohol", "bleach", "nailpolish remover", "cigarettes" or any other dangerous stuff you can find in the household that are supposed to be locked away when children are around. Yes, most of these are smelly, but toddlers can be too curious for their own good and are not that discerning for bad tastes yet.
Worse than a loaded gun? That’s insane, the gun can kill you. LSD can’t. There are a multitude of things in every household that a child could kill themselves with (various medicines, cleaning supplies, knives). That is not a reason to ban those things, it’s a reason not to leave small children unattended.
A child seems more likely to harm themselves with a kitchen knife than a blot paper lying around. But sure, I would support laws that makes you legally responsible for safe handling of the substance, like not giving it or making it accessible to minors.
When I was arrested and searched the police didn’t even find the 200 tabs I had on me.
They found everything else, but LSD is incredibly easy to hide from regular law enforcement.
They found everything else, but in typical stupid-police fashion, they ballsed that up too and ended up entering a nolle prosequi (do not prosecute) at the district court level.
The police prosecutor was sufficiently annoyed, and I was sufficiently elated and thankful for the woman who went before me (case unrelated) and set a strong precedent.
Any chance I get to gloat.
Edit to add: this happened in Australia in 2012. Not keen to repeat the experience.
> but LSD is incredibly easy to hide from regular law enforcement
Not that I intend to leverage that knowledge, but you can't just write this and leave it at that. Why so? I've never seen any LSD, so I am not sure why that would be.
Most people who have taken LSD have never seen any LSD either, because the dosage is so small. A strong dose is something like 300 micrograms--this amount of crystal is almost invisible to the naked eye.
This also presents problems for chemists, because measuring out such small amounts is prohibitively difficult. So typically they dissolve a measurable amount (say, 30mg) into a volume of liquid (water or alcohol) and distribute it across a sheet of blotter paper divided into 100 squares, so that when the liquid dries, each square contains the desired dose (in the example, 300mcg)[1]. This is why the image most people have of LSD is a half-centimeter by half-centimeter square of paper--they're not seeing LSD, they're seeing the paper the LSD crystals are trapped in.
Since I'm posting this under my real name, I should clarify that the reason I've researched this is that I did volunteer harm reduction at festivals. I don't even drink alcohol, let alone take drugs.
[1] To be clear, LSD at stable temperatures is a solid crystal. There's no such thing as "liquid LSD"--that's LSD dissolved in a solvent.
Thanks a lot for this insightful comment. I guess it could be hidden in any liquid or absorbing medium (paper, cardboard, textile, sponge, whatever... thus making it easy to conceal).
I had no idea the drug was that potent... Presumably some neurotoxins have the same potency? This is quite scary to think of.
This document (PDF) from the Multidisciplinary Association for Psychedelic Studies (MAPS) claims:
The LD50 of LSD varies from species to species. The most sensitive species is the rabbit, with an LD50 of 0.3 mg/kg i.v. [52]. The LD50 for rats (16.5 mg/kg i.v.) is much higher [52,53], though mice tolerate doses of 46– 60 mg/kg i.v. [52,54]. These animals expired by paralysis and respiratory failure. Monkeys (Macaca mulatta) have been injected with doses as high as 1 mg/kg i.v. without any lasting somatic effects [55].
There have been no documented human deaths from an LSD overdose. Eight individuals who accidentally con- sumed a very high dose of LSD intranasally (mistaking it for cocaine) had plasma levels of 1000–7000 μg per 100 mL blood plasma and suffered from comatose states, hy- perthermia, vomiting, light gastric bleeding, and respira- tory problems. However, all survived with hospital treat- ment and without residual effects.
You're correct that no one dies from LSD overdose, but there are other serious concerns here. High doses of LSD can result in hallucinations so extreme that the person is not seeing reality--they're literally blind. A rational reaction to this might be to sit down and wait for the trip to pass, but people on giant doses on hallucinogens may also be experiencing high energy and restlessness which cause them to move around and run into things, fall down stairs, etc.
I met a person who, while on a ~1/2 lb dose of psylocybin mushrooms, fell face first down stairs onto a train platform without even putting his hands out, breaking his nose, smashing out all his front teeth, and getting a severe concussion--it's easy to see how this could have been much worse had he fallen off the train platform.
And that's just the physical effects. I've met a few people who were fingerprinted (moisten a finger, press it into a tray of crystalline LSD, and consume whatever sticks to your finger) and at those doses, they all reported long-term hallucinations (in medical parlance, hallucinatory persisting perception disorder or HPPD). Others were diagnosed with PTSD after bad trips (one reported being "psychically attacked" by evil spirits, another was convinced that everyone was trying to kill him).
There are numerous cases of people being assaulted sexually or violently while on hallucinogens, and feeling that they could have defended themselves had they not been tripping. That's not to say they are to blame for the actions of their attackers. People who are on drugs are vulnerable, but the reaction I'd like to see is not to blame them, but instead for communities to care for them and protect them while they're vulnerable.
Now, I'm well aware that as someone volunteering in harm reduction, I only got to see the bad cases. For every patient reporting a negative experience, there are hundreds if not thousands of people who use hallucinogens and have positive experiences. I'm not against drug use, I'm merely advocating that people do so in an educated, responsible manner, understanding the very real risks they're taking. Just because the LD50s of LSD and psilocybin are very high, doesn't mean that a high dose of these drugs is not risky.
Blotter sheets and disguised in other liquids in plain sight. For example, if you were to sell LSD it could be as disguised as being a simple spiralbound notebook, but the parties in the know understand that the cardboard backing is entirely laid with LSD.
There is a famous story of how the album from Plastikman (Richie Hawtin) had a blotter paper album cover that was perforated landed someone in jail because they thought it was LSD. The father of the son arrested contacted the label (novamute I think?) and they shipped another copy to the law enforcement agency to explain.
Sheet One is the title of it, not in a position to share the URL but please take a look. Great album and artist too.
You see giant protests occupying cities for weeks and your first thought is that americans are totally OK with the state of things? All those folks on the street in Hong kong - they must just be out there celebrating their loss of liberties! It's a big party!
Continued gerrymandering keeps the incumbents in power. Ongoing voter suppression targeted at minorities silences their political voices and swings elections, denying democracy its due. Since 1990, the Republican party has won the popular vote for president once, but won the presidency 3 times. 2018 was a wave year where the left picked up a huge number of seats in the house. And the federal government isn't everything. State and local governments hold enormous power, and where progress can be made, progressives are elected. Theres also huge amounts of money in politics thanks to a really destructive supreme court ruling. And do you really think the people in Minneapolis protesting are going to vote for trump and support officials that refuse to serve their interests? I understand you might not be familiar with why people are protesting and the ways the political system is broken. Hell, I don't know what's going on in the UK with brexit and their protests everything for example, and I dont know what the electoral dynamics and structural problems are. And that's fine, because I'm not going around oversimplifying issues I dont understand and saying "wow these dumb Brits are so self destructive why do they keep voting for dumb stuff." Same thing. I'd recommend actually understanding what's going on before making sweeping incorrect statements about how America works. Again - Americans electing leaders that refuse to serve "their" interests. Do you think this deeply politically divided country is some sort of monolith? Do you really think the people protesting are the ones that voted for Trump?
Indeed.. When the public has only two candidates to realistically choose from, both of whom represent parties which run on massive legalized bribery ("donations") and coordinate to systematically keep incumbents out - it's not fair to blame the American public for "electing" leaders that maintain and strengthen the status quo. They don't really have much of a choice.
Not really. When you ignore all the marketing material about "freedom" and such that accompanies a discussion about the US, you see that we are an extremely authoritarian country.
Well to be fair. If more population were concerned an actively participating in democracy, by at the least get out and go to vote, some thing would change, for sure.
USA has the lowest participation on any democracy I know.
Universal obligatory vote is something that does wonders and produce actual change.
I do vote but I also live in a gerrymandered district so my representative is pre-chosen for me. I also live in a non-battleground state where essentially my president is pre-chosen as well. My vote actually doesn't matter much at all.
To make an example out of them and discourage others, prevent a cottage industry from forming. LSD manufacturing scales immensely. One lone wolf could create enough LSD to serve the whole United States demand, maybe even the global demand. LSD is also harder to manufacture. You generally need at least a MS degree and lab experience. The people who fit that profile tend to think about the future enough to respond to the possibiliy of a life sentence.
A friend of mine once asked his TA about (my memory fails here) either how to activate a leaving group or set up a protecting group at a given hypothetical structure. The TA, without batting an eyelid, responded "I think you'll find all the precursors are scheduled, too." The next lab, the TA, presumably having reflected a bit and in the middle of an unrelated discourse, added "remember, always characterise any synthesis you undertake."
Edit: (ratelimit, sorry)
group: small chemical structure manipulated in a single synthetic step. See also
scheduling: I have no idea, but it seems likely that at least all the easy precursors were. (ChemE, like systems CS, is all about tradeoffs. It's unlikely anyone bothers to schedule precursors along very difficult synthetic routes. Just like CS people have the IOCCC, synthetic chemists sometimes do small batches with pathways no ChemE would use, just because they're there.)
characterisation: One should do this anyways, to discover if what one has made is what one had intended to make. (compare with unit testing) In the context, I'd consider it a warning that one should especially do this if one plans to partake product.
TA: teaching assistant (post- or just pre-MS in this case, definitely with lab experience)
The punchline is that the TA could guess the intended product given only a single synthesis step for a partial structure. (To be fair, computer geeks love discussing black hat activities, so it shouldn't be any surprise chemists are up on the "abuses" of their science to the same degree.)
What is a group? (Group of people, or some chemical compound, or some kind of corporate structure, protecting possibly illegal stuff going on in one of the groups?)
Are all the precursors scheduled, or is the punchline that the TA was wrong?
Why would one do well to remember to characterise any synthesis undertaken? To protect oneself against legal action by showing that the labs purpose was synthesising legal compounds?
Upvoted because these are good questions, indicating a genuine willingness to understand exactly what another poster is saying. That’s the kind of discussion that I come to Hacker News for. Not everyone has the same background and understanding of terminology and they shouldn’t be down-voted for that.
When you do a reaction on a chemical, the reaction can often affect multiple different parts of the structure, even if you only want it to affect one site. So, you can pop a "protecting group" onto the site you don't want modified, and then remove it later. https://en.wikipedia.org/wiki/Protecting_group
A TA is a teaching assistant; typically a grad student with lots of knowledge teaching a class to undergrads.
You would want to characterize any synthesis- verify your work to make sure you got high quality product that is pure.
The 'groups' are chemical structures present in a compound. The student asks the Teaching Assistant (typically a graduate student who is required to do teach) a general question about how to carry out a multi step process to selectively transform specific regions of chemical compounds.
The punchline is that the Teaching Assistant immediately sees the intent of the question, and goes from the general to the specific and replies: [ you won't be able to synthesise LSD with that approach because ] "all of the precursors are also scheduled."
You design your synthesis around this and try to pick pathways that are easy, have the highest yields, and don't produce undesirable products you have to remove.
In the 1970s, my father worked as a research chemist for CSIRO (Australian government research lab), doing research into new pharmaceutical products. One of his colleagues decided it would be fun to manufacture some LSD after hours for personal use. The colleague made an error in calculating the quantities involved and ended up taking an accidental overdose. It didn’t kill him, but he spent some time in a psychiatric ward as a result. (I’m pretty sure my father was too responsible to try any himself.)
My brother did chemistry at university too. Did an internship at an Australian government laboratory (National Measurement Institute) at which he got to manufacture MDMA - completely legally, it was part of a research project into different synthesis routes, so that by measuring traces they could determine how street samples were manufactured. He must be one of the few people in the whole country to synthesise ecstasy without breaking any laws in doing so. (They were very careful to ensure none of the staff sampled the product; it was all weighed very precisely and signed off by multiple people from precursors to synthesis to analysis to destruction.)
There have been reports of huge overdosis, e.g. by miscalculation by a factor of 1000 or even more.
The physical harm was little to none. The mental harm varied greatly, there were even some people who got improvements in pre-existing mental conditions; with lsd in general, but also with large overdoses in particular.
The former Pink Floyd band member Syd Barret fried his brains from LSD but it is not clear whether he ODed or did too much of it over a long period of time. Once the initial paranoia subsided he became a complete recluse.
Having said that, I think LSD is a fantastic drug but that is not for everyone. I’ve got a friend who did it constantly for over 2 years and he is a completely sane person. He claims it was one of the experiences that put an end to his alcoholist tendency which might as well be genetic. His dad died due to alcoholism.
This, too, is an armchair diagnosis and unnecessarily sensational language. According to Wikipedia:
> Asked if Barrett may have had Asperger's syndrome, his sister Rosemary Breen said that he and his siblings were "all on the spectrum".
> Waters maintains that Barrett suffered "without a doubt" from schizophrenia. In an article published in 2006, Gilmour was quoted as saying: "In my opinion, his nervous breakdown would have happened anyway. It was a deep-rooted thing. But I'll say the psychedelic experience might well have acted as a catalyst. Still, I just don't think he could deal with the vision of success and all the things that went with it."
“Fried his brains” is a figure of speech and not a diagnosis. Not to be taken it literally that Syd fried his brains as in frying an omelette. But after doing a lot of LSD seemed to be a turning point in his life.
A case report from 1974 says that massive LSD overdoses can cause bleeding and hyperthermia, symptoms which could potentially be fatal without medical attention (but, in this case, medical attention was received and all survived)
Wow, I wonder if they spoke about it publicly after the fact. There aren't a lot of stories like this. Did they remember the experience? Was it really a coma or some out of body experience? It would be interesting to see how differently their lives went versus their peers.
What hype? I think it is very likely that a sufficiently high dose of just about any drug, LSD included, will kill someone. If no one has died yet, that just means no one has ever taken a big enough overdose.
We know the LD50 of LSD in rabbits, rats and mice [1]. Surely, there exists a human LD50 as well, it is just that hopefully nobody will ever be evil enough to do the necessary human experiments to determine it. (That's true for all drugs – just because we can't ethically discover the human LD50 doesn't mean one doesn't exist.)
What's the biggest overdose anybody has ever taken? This case report is the biggest one I know about. And yet, they each only consumed "two lines" of 3mm by 4mm by 30 mm, which is less than a gram, administered nasally. They were hospitalised. Would they have lived without medical attention? We don't know, but quite possibly not. And surely it would have been physically possible to take an even bigger overdose than that. How do we know an even more massive overdose would not have been fatal?
People rarely take LSD intravenously. I think a fatal overdose of LSD would most easily achieved with intravenous administration. That's what the animal study LD50s are calculated based on.
Unless you are trying to commit suicide or murder, you wouldn't do it. And if you are trying to do either, there are far more practical methods than massive LSD overdoses.
EDIT: I deleted my back of the envelope calculations about how much the people took in mg/kg. I don't have confidence I'm doing it right so better not to.
i once took 82 hits of acid. ahh, to be 17 years old and think you're invincible again.
each hit was a gellcap with about 4 hits like blotter paper. this was at an outdoor rave-festival.
i was curled up in a ball in a tent for 2 days. fully immersive hallucinations. the good thing is when you are so incapacitated, you cant get up and move around to hurt yourself and others. i had sitters watching me and feeding me water.
nothing happened. i slowly returned to sober consciousness with zero bad physical side effects. except dissappointment that i had missed the entire rave.
that was the greatest spiritual experience i have ever had. none of the hallucinations were scary or negative, likely because the setting was outdoors on a rural camp ground in nature. i was talking to the Sun. and the blades of grass. and they talked back. i felt an indescribable oneness with all living beings and a realization that all life is sentient. meaning that our "human consciousness" model is just a tiny sliver of the full spectrum of "living consciousness", only we dont see the greater consciousness while we go about our daily lives trapped inside our limited minds. as an analogy, think of human consciousness like a language--C or assembly. then Universal Consciousness is like Leibnitz's mythical Perfect Language which simultaneously describes and creates our Monadic world.
decades later, that experience is still one of my happiest and i can remember it more vividly than more recent milestone events.
i understand why Steve Jobs said his first time tripping was his #2 greatest life experience.
if you ever have the opportunity to take 360 hits of acid, i recommend you go for it. you will see God and it will permanently reprogram your brain.
You also need precursors (like ET) which is difficult to get. Though China is a pretty good source if you can pull it off (and for other things like safrole, etc.).
Difficulty is relative. Laundering Sigma Aldrich purchases at scale is challenging but not out of the realm for the level of resources + expertise needed for an LSD manufacturer.
It's not "backyard meth lab ordering 40ft container of pseudoephedrine" levels of ridiculous.
What's ET? It's pretty difficult for me to Google this acronym given that it mostly finds "et al" when I couple this with LSD queries. Is it ergotamine from the other subthreads here?
As does Psilocybin in Magic Mushrooms. Back when we used to sell the stuff (UK, 2005 or so), we had a small 'lab' (a grand term) run by someone who suffered serious cluster headaches and had gotten involved with us through our selling of 'shrooms.
We used to sell to quite a few people who similarly suffered from the condition, and used mushrooms to treat it - but it was an impossible thing for us to market or advertise, due to the way the MHRA (Medicines and Health Regulatory Agency) dictates what beneficial claims can be stated about retailed items.
On the other hand if you have a migraine while tripping, it's not great. Taking triptanes is, well, risky as their interaction has not been thoroughly researched (i wonder why) and they both do stuff to HT receptors - so it's probably safer to endure the trip and take drugs afterwards. Good thing is that on LSD it is not "you"that suffers, just someones' body ;)
Various parties have pulled it off in recent years, as AL-LAD, 1P-LSD and a couple of other very close relatives (not prohibited at the time in various countries), have been produced and sold (mostly) legally in a variety of countries.
Considering that this is coming from the same drug culture that uses the word "molly" refer to "some mixture of empatheogenic drugs and possibly some amphetamine", expecting specificity from your terminology is a bit unrealistic.
I'm not (just) being judgmental here: volunteering harm reduction at festivals, the number 1 problem we had was that users had no idea what they had put into their bodies.
Actual chemists, no doubt, don't use any of this terminology since chemical reactions don't produce the desired results if you're vague about what you put into them.
The way I learned it, if you mix an acid and a base, you get a salt and water. Table salt (NaCl) is the result of mixing hydrochloric acid (HCl) and sodium hydroxide (NaOH):
HCl + NaOH -> HOH (water) + NaCl
But if you mix a different acid and a different base, you'll get a different salt, for example if you mix sulphuric acid and calcium hydroxide, you get calcium sulfate:
Organic chemicals are often “salted” to cause them to precipitate out of the solution they’re synthesized in. It’s a salt in the chemical sense, but not in the culinary sense.
My friend who is a pharmaceutical chemist said LSD is actually quite difficult to make, compared to other illicit drugs:
- Lysergic acid is a relatively fragile molecule and will fall apart if exposed to harsh reaction conditions. Compare that to say methamphetamine which can survive strong acids/bases.
- It’s also light sensitive, so you need to protect from light which is why you see the red light setup in LSD labs
Do criminals actually respond to deterrents though? Sam Harris argues otherwise in a couple of podcasts and I tend to agree...people break the law constantly without thought of the penalties. People text while driving when that could kill someone else.
I don't really believe anyone reacts to harsh deterrents for a low probability outcome. The only way is to increase the probability of being caught, but that's super super hard. So instead, we just throw the people we do catch in jail for life.
It's so fucked up, it makes me disgusted even thinking about it.
I don't believe they do either. For example, it's often said that the death penalty is used as a deterrent, though it is clear from the data that isn't true.
LSD use is actually higher than it has ever been in the US. i apologize for lacking a source, but this was something i saw about a week ago, in the context of highlighting its relative popularity with young, college-educated americans.
that said, it’s hardly a cash cow in the way meth and fentanyl are; and as someone said elsewhere on this thread, one person could probably suppy the whole country.
I'm 99,9% positive demand for LSD is not higher than it has ever been in the US because of the hippie era, when it was huge.
The problem with LSD as a product is not only that few people use it. Amongst those that use it, most won't use many times.
Compared to my social circle I'm a pretty heavy user, had around 30 trips in the span of almost 15 years. Most people I have met didn't trip more than 3 or 4 times in their lifetime. A few from 5-10, and only 2 or 3 over that.
The only reason LSD is and was in the past cheap is because of how easy it is to scale it's production + how high the barriers for production are. Otherwise a hit would cost very very high, considering the economics of the matter.
You’re probably right about the demand. Our population is higher now, and there’s the microdosing trend to account for, but it’s certainly not in the public consciousness in the same way cannabis is—I’m almost as certain that that IS higher than ever.
I’m curious about your last statement. Scaling makes sense as a cost factor, but are you saying that lower barriers for production would increase the cost? That seems backwards to me.
I perceive microdosing as a very fast dying fad, but it's only an opinion of course.
About the cost, the way I understand it, the definitive factor is scalability. It's MUCH more scalable than the production of other drugs. If this was not the case, it probably would be VERY expensive, because of the very high barriers to entry and very low and distributed demand.
LSD is not something Mexican cartels would be interested in. It is far, far more difficult to manufacture than growing plants (marijuana, cocaine, heroin). And the demand is nowhere near as much as the drugs they typically sell. LSD is also not addictive and thus not nearly profitable enough for them to consider.
With some "seed money" I'm sure you could get a lot of it in India or China. The people who work in those factories are the same people who put lead paint on children's toys to save a few dollars. Its precursor literally does grow on wheat plants but I digress.
Yeah the whole point of the war on drugs for the most part was to punish people who wanted to see things differently. There are only a few scheduled drugs that are actually harmful. If alcohol were discovered today it would certainly be scheduled because its side effects and potential for addiction are far worse than EG todays normal dosage of MDMA or LSD. The whole notion of jailing drug users actually made their lives far worse than the drugs themselves ever did. And the aggressive prosecution created openings for the modern drug cartels by eliminating competition.
Nope, much earlier. MKULTRA, the secret CIA program to administer LSD to do mind control and other stupid shit, started in the 50ies under the Dulles bothers already. https://en.wikipedia.org/wiki/Project_MKUltra
They also did lots of public advertising for LSD via popular figures like Timothy Leary, besides frying a lot of innocent brains with it.
I know that perfectly well, hence the scare quotes. I was referencing the term used by the person I replied to in order the draw a parallel between the two.
The thing that makes meth heads and crack heads dangerous is primarily that the users are desperate for money to feed their addiction and thus more likely to commit crimes to make money. Coke heads probably started out fairly wealthy, since it's a more expensive drug, so they are less likely to resort to theft to pay for their addiction. It's probably also somewhat of a social class issue. Crack and meth users are probably more likely to have grown up in rough circumstances that make them more likely to commit violence whether or not they are under the influence of drugs. Reporting bias is probably also a bit of an issue. If a rich coke user assaults someone they may be able to sweep it under the rug by writing a big check to the victim, whereas a poor user would be thrown into the criminal justice system. A final hypothesis is that cocaine users have more resources for dealing with addiction (such as rehab) than other drug users. That would skew the population of active coke users towards recreational users rather than addicts.
There are chemical differences between crack, meth, and cocaine, so it's likely that, ceteris paribus, crack users are more violent than coke users, but it's not the only factor. It's really hard to tease out differences in the effects of the drugs when the populations of users are so different.
[...] The likelihood of violence associated with crack cocaine users was greater compared to powdered cocaine users at the bivariate level. However, these differences were almost uniformly statistically nonsignificant when demographic, mood and non-cocaine substance use disorders were controlled for. [...]
Meth and crack are both cheaper than coke, which results in class/socioeconomic effects in who uses them as well as how they're portrayed in media and handled by government.
An other difference is that snorting coke leads to a somewhat delayed, milder and much longer euphoric effect. Injection and smoking lead to much faster, more intense and shorter highs. So the differences in methods of consumption would lead to very different patterns of behaviour as well e.g. it's less likely that you can do things on a crack high than after snorting coke, and the intensity of the high would lead to increased odds of chasing the high.
Plus the duration of the high means that you'd necessarily have to spend more time (relatively) chasing that high or ways to achieve it.
I agree, just to add in my own words -- it gives you a fresh perspective, as if your staring at the world from the eyes of a tree. But is it really that important for those in power to maintain a certain narrative/perception? These sentences sound too rough..
IMO, yes, because there is nothing holding the country together besides the perception that the US constitution protects & ensures our freedom. If that perception falls, then there could substantially greater political unrest, even moreso than what we have experienced this summer
And LSD and other psychedelics definitely make you rethink the validity of government, period. Let alone the efficacy of the powers that be to ensure safety and prosperity
> IMO, yes, because there is nothing holding the country together besides the perception that the US constitution protects & ensures our freedom.
What holds the country together is a lot of people have a lot to lose.
> And LSD and other psychedelics definitely make you rethink the validity of government, period. Let alone the efficacy of the powers that be to ensure safety and prosperity
But this is just the crux of it - it is an illusory experience that has some impact on the user. It isn't any arbiter of truth or knowledge.
> There are many things that "hold a country together" - some of them are known (here we have two examples), and others are unknown.
Exactly - that's a far cry from your claim. It's likely that the two reasons we posited on their own are meaningless.
> It is surely illusory to a very large degree, but "what it is", really, is far beyond mankind's ability to judge such things.
And yet in this very thread claims and judgements are made how it can topple governments, makes free thinkers, is the panacea to everything, just like weed cures cancer and saints cured the sick. How the government suppresses it because it will hurt those in power and prevent the utopian LSD world that is clamored for.
It borders on religious fanaticism - plenty of drugs and visions lead to jihad as much as kindness and love.
That's part of what makes life interesting, the amazing power of the imagination (often indistinguishable from reality), but no way of knowing what will actually come to be, except sometimes the passage of time.
There was definitely unreasonable fear around LSD. I remember my parents not allowing us to use temporary tattoos because they were concerned they might be laced with LSD.
One reason was that the government didn't like the people using the the psychedelics in the first place, and drugs were a convenient justification for going after those people. Marijuana prohibition in the US is the same story.
I came here to make a comment about CIA's Project MKUltra so I'll just add a quote about the use of LSD from the Wikipedia article:
> [...] experiments included administering LSD to mental patients, prisoners, drug addicts, and sex workers—"people who could not fight back," as one agency officer put it. In one case, they administered LSD to a mental patient in Kentucky for 174 days.
In the 90s the feds tried to go hard on gun crime and that just got them a bunch of pictures of crispy children on the news, not exactly the look they were going for.
In the world of use it or lose it budgets cracking down on psychedelics seems like a pretty safe way for the DOJ to keep burning money without incurring too much negative publicity.
The Government is very familiar with LSD, having used it for a wide variety of research over an extended period of time. LSD has proven exceedingly effective at behavior modification, and has already been put to use by the wrong hands. So, they know better than anyone as to how dangerous it is: https://www.amazon.com/Tom-ONeill-ebook/dp/B07K6J273Q
I’m dismissing the book as pure speculation and horseshit, because it is. Charles Manson used tactics that have been used to control people throughout history: fear, abuse, intimidation, isolation from society, and violence. He’s not the first or last person to develop a cult of personality.
I’m well aware of MKULTRA and the CIA’s involvement in that program.
Please provide a source that shows mind control is possible with LSD.
Tobacco and alcohol industry are getting government subsidies, bailouts and huge profit margins. Not sure about the other "illegal" drug manufacturers.
It's more acceptable and state-sanctioned to sell drugs that kill people while keeping them subdued, than ones that keep them alive and open their minds.
I don't want to sound like a crazy 'conspiracy theorist' or a 'hippie', but I don't know to distill this sad and truthful statement more simply than that.
The problem with what you're saying isn't how it sounds, it's that there's no evidence for what you're saying.
My understanding, looking at the history of psychedelic regulation, is that it had nothing to do with preventing people from opening their minds: the people who did the regulating don't think the concept of "opening your mind" even exists. I'll let John Ehrlichman (Nixon aide) explain:
"The Nixon campaign in 1968, and the Nixon White House after that, had two enemies: the antiwar left and black people. [...] We knew we couldn’t make it illegal to be either against the war or black, but by getting the public to associate the hippies with marijuana and blacks with heroin, and then criminalizing both heavily, we could disrupt those communities. We could arrest their leaders, raid their homes, break up their meetings, and vilify them night after night on the evening news. Did we know we were lying about the drugs? Of course we did."
You might say, "well that's the same thing as being against opening minds" but it's really not. Keep in mind, a lot of times cops simply planted drugs on people to arrest them: why would they wrongly accuse someone of trying to open their mind if their intent was to prevent people from opening their minds? The answer is, that wasn't their intent. They didn't plant drugs on people to prevent them from opening their minds, they planted drugs on them because they were black or antiwar.
Agreed, but in a response to a comment whose claim is "It's more acceptable and state-sanctioned..." without differentiating who is doing the accepting or what elements of the state are doing the sanctioning, I think we've already accepted a level of oversimplification.
Reality is always more complicated than anyone says.
The reasons why tobacco and alcohol are legal are mostly historical and they are basically the only exceptions.
There are many drugs that kill people but keep them subdued that are illegal. It seems to me that is not the reason for which are legal and which ones are not.
I agree with tobacco. However, alcohol is legal in part because it’s easy to make. Even prisoners often start making alcohol let alone the general public.
That’s an over simplistic and not realistic view. Marihuana had a similar history as tobacco, opiates go back thousands of years, caffeine is deemed fine, alcohol was actually illegal for years, etc.
Considering the counter culture and anti war (and thus anti military industrial) sentiment being highly correlated with hippies getting lit—I think it’s impossible not to come to the conclusion that the powers that be consider mind expanding drugs to be a threat to the order of things.
Yes I was simplifying quite a lot. But "historical" wasn't just meant as "was there already", even though it plays a huge part.
As far as I know, marijuana was mostly made illegal in the 30s and earlier in the US, mostly due to racist origins and with arguments mostly opposite those of hippies (e.g., creating bloodlust).
I forgot about Caffeine, that's true, as it is often not considered a drug by many (or at least not taught as one). But it's also not one of a dulling effect, as far as I can tell at least.
That they tried to make alcohol illegal and failed because of it's societal acceptance is another indicator that the original claim is not so obviously true:
> It's more acceptable and state-sanctioned to sell drugs that kill people while keeping them subdued, than ones that keep them alive and open their minds.
Overall it feels more that the general Zeitgeist of regulating narcotics failed on alcohol but succeeded with often racist propaganda for other popular drugs.
But that's just my understanding and I am not very well versed in any of those topics, so I'd be happy to listen to a better explanation. (I wouldn't be surprised that anti-establishment gatherings with strong drug usage correlation wouldn't exactly make legalisation popular in the establishment. But the history article I read on that just now claimed that sentences were reduced during the 70s because of the wake of hippies.)
You might sounds less like a 'hippie' if you avoid the phrase 'open your mind'. It implies that psychodelics provide users with some kind of enlightenment rather than just hallucinations and euphorea. Makes it seem like anti-drug politicians are trying to hide some sort of dark secret which can only be unlocked by taking LSD.
The common miscommunication here is that people perceive the statement as saying "psychedelics are the ONLY way of learning certain things", whereas what they should perceive is "psychedelics are ONE (very efficient) way of learning certain things".
The thing is that for people whose normal life does not include pursuing knowledge and understanding just for the sake of it (and I think this might be most people), it's unlikely that they'd end up with the right perspective shift through some other circumstance.
Which is quite remarkable given the stability these personality traits usually have.
Overall while it seems to be clear that people who take psychedelics don't become saints spreading love for the rest of their lives, there's some solid evidence accumulated by psychologists that psychedelics have some real effect.
I don't know what you'd consider "credible evidence". You can find tens of thousands of anecdotal accounts, but you're probably looking for something more formal.
It's likely a futile search: Research into these topics is difficult to get approval for, even when it's more "tangible" things like effects on depression or PTSD. In my opinion, we'll probably need another few decades to get there (though there has been some encouraging societal progress in some places recently).
We won't get anywhere in this conversation because we're on two different sides of a fence, and I certainly can't describe what being on this side is like and can only invite people to come over here. It'd be like asking you to describe what the colour green looks like to you.
Which path around, or over, the fence they choose is up to them ...
There's tons of evidence available online, but a big problem is a lack of agreement on what constitutes "credible evidence". There is a fairly significant amount of clinical evidence available (despite it being effectively banned from study for decades), but the vast majority of evidence available is anecdotal reports from users. It should be noted that while it's true that this class of evidence lacks a "proper" (standards double blind placebo-controlled, etc) approach, it does not logically follow that it is therefore incorrect.
As for where to point skeptical-minded people, I agree with others that Sam Harris is one of the better resources.
Here is an article on his recent 5g "heroic dose" mushroom trip:
> “There’s no denying that there were parts of the experience that felt like an encounter with something other than my own mind,” Harris says, something that guided him “across the landscape of mind.” Many trippers, Harris notes, interpret this something as god or a universal consciousness. Harris suspends judgment. “My day job is not to be fooled by spurious ideas passed down from our ignorant ancestors, so I’m very slow to make claims about what I think is going on here,” he says. “I’m just reporting the character of the experience.” In the end, Harris says, “I thought of this as the mushroom itself.”
> Thus Harris captures the magic and intrigue of psychedelics: the parsimonious explanation for the encounters you feel on a big mushroom trip is that you’re being guided by a fungus. Harris himself is astounded. “The fact that there are landscapes of mind this vast lurking on the other side of a mushroom is simply preposterous,” Harris goes on. “It’s as though we lived in a universe where, if you just reached into your right pocket with your left hand, rather than pull out your wallet, you’d pull out the Andromeda Galaxy.”
When I first heard of Harris about 15 years ago, back when psychedelic use was still a relatively underground phenomenon and the so-called Psychedelic Renaissance was just beginning, I never dreamed I'd ever see a militant atheist like him transform in to a psychedelic advocate taking "heroic" mushroom doses and having what could be described as powerful mystical experience, even if he's not comfortable using such terms for what he experienced.
I do wonder if his atheism would survive more such powerful experiences. Already, from this one experience, he speaks of understanding how such such an experience could be interpreted in religious terms by those who were already religious. Again, such empathy and understanding is not something I would have expected 15 years ago from such a militant atheist.
Even if he never trips again, I have to commend him for being open-minded enough and curious enough to try psychedelics multiple times, and once at a relatively high dose. Many more close-minded people, who feel completely confident in an extremely one-sided world view, would never chance having their perspective radically altered with psychedelics. Yet he did. Kudos to him for that. If more people were so inquisitive and open-minded the world might be a much better place.
That's not to say that I view psychedelics as a panacea, and I agree with Harris that they're not for everyone. Their use entails real risks, and they can easily be misused by taking them without an experienced guide, without preparation or respect, or in the wrong set and setting. But at the same time, when used constructively, they have a profound potential for encouraging empathy, open-mindedness, improved cross-cultural and cross-denominational communication and understanding. Harris' experiences and transformation are evidence of this.
I'm not such a big fan. To me, I am constantly baffled by how on one hand he has first hand knowledge of altered states and the deep, unusual perspectives that come with them, but then he goes right back to conceptualizing the world mostly at a simplistic object level. Perhaps he should trip on a more regular basis so some of the ideas stick better.
> about 15 years ago, back when psychedelic use was still a relatively underground phenomenon and the so-called Psychedelic Renaissance was just beginning,
15 years ago? Huh, I thought it had only started a couple years ago.
The central revelation, as I see it, isn't so much about facts or content (e.g. truth, purpose, ultimate meaning) but rather about how flexible the hardware/software package is that underlies our cognition and sense of the world - the experience of your mind behaving in novel ways.
I suppose there's nothing terribly transcendent for observers about seeing Doom run on an iPod, but it's definitely surprising to see how the flexible the hardware/software can be.
Subjectively, though, it can feel pretty transcendent when its your runtime being hacked in new and different ways.
If the iPod had a sense of self like we do then maybe it would be floored seeing itself run Doom (though hopefully it wouldn't confuse Doom for ultimate truth).
"The mind is vaster and more fluid than our ordinary, waking consciousness suggests. And it is simply impossible to communicate the profundity (or seeming profundity) of psychedelic states to those who have never experienced them. Indeed, it is even difficult to remind oneself of the power of these states once they have passed."
Open the mind is a figure of speech. If you think its hippie, you have your speech buried in the 1960s. Opening the mind is about accepting sensory data without mental heuristics (like concepts) titled over everything.
Opening the mind is used a lot in Buddhism and meditation to describe how consciousness is not inherently stuck in loops of negative thought, but that by opening the brain's perception of anything happening, we can see more clearly and without egocentric concern.
If anyone reading is thinking psychedelics and meditation are just hippie mumbo jumbo, check out Sam Harris or Dan Harris or Joseph Goldstein, who will show you how meditation is useful and not woo woo.
I like to take that to the extreme and say -- how many hospital beds would be empty and pill shelves full if these drugs weren't around? How many dentists would be out of the biz if they didn't shove glue-like candy in our childrens teeth? Then I see that I'm being silly and take another swig.
As zelly notes below the US has mandatory life sentence for certain amounts of drug production. Under 21 USC § 848(b), a life sentence is automatic for the principal administrator of a "continuing criminal enterprise" involving in excess of 300 times the quantities listed at 21 USC § 841(b)(1)(B), which for LSD would be (v):
> 1 gram or more of a mixture or substance containing a detectable amount of lysergic acid diethylamide (LSD)
By all accounts, Pickard had produced kilos of LSD.
Not defending the life sentence (let alone two concurrently), but it's a logical consequence of the US's fucked up laws & sentencing guidelines.
> Wonder what people were getting for drugs that actually kill people.
Depends, were they "black" of "leftist" drugs that "actually kill people"? I don't think anyone got jailed over leaded gas.
In the US? Not really. Its sale is banned for use in cars. Wikipedia says there are a few exceptions for aircraft, farm equipment, and marine engines, but even in those fields I've never heard of it being used. It's also been pretty much phased out worldwide with a few tiny exceptions. What exactly are you referring to?
You're right, but only technically. Leaded gas is in use in GA aircraft only. The overall contribution this makes to atmospheric pollution is infinitesimal. Diesel garbage trucks are worse for society the amount of leaded gas we still burn.
if the drug legalization momentum keeps up in the US, he might be back in business one day - which would be awesome. psilos are great and all but LSD brings the right amount of fun to tripping in my experience.
I found this line from the article particularly interesting:
“The court concluded that the 20 years served are sufficient for meeting the goals of incapacitation, deterrence, retribution, and rehabilitation.”
Deterrence and rehabilitation (yeah, right) I knew were “goals” of the US prison system, but I never realized that “incapacitation” and “retribution” were actual legally-stated goals.
I'd argue that if the intention is entirely to rehabilitate (and incapacitate if necessary) then a prison sentence would only incidentally be a punishment.
Don't get me wrong - I don't believe that the US "justice system" is at all concerned with rehabilitation. Giving 2 life sentences to a non violent drug offender is ridiculous.
There are different theories of criminal punishment (i.e., different people subscribe to different philosophical justifications). Incapacitation is basically a special case of deterrence, in that you're deterring the individual who's in prison. Retribution is a little more controversial, but plenty of people see it as a valid goal.
You don't give someone a life sentence to rehabilitate them. At some point, you have to recognize that certain people are dangers to society and need to be "incapacitated" from causing further harm.
Incapacitation makes sense, no? Would we not want to incapacitate a serial killer's ability to serially kill? If we really believe crime is bad then we should want to incapacitate people from committing crimes.
Under the Federal drug kingpin law[1], after certain thresholds[2] of business having been done, the minimum sentence is life. For example, the threshold for a life sentence for cocaine is 1500 kilograms, for LSD 300 grams. Doesn't matter if you were violent or not. No suspensed sentence, no probation, no parole (Pickard seems to have gotten an exception because of coronavirus like many others).
>> This man made a product that others willingly wanted for themselves. There are no victims here
People may think LSD or cocaine is all well and good, but there are far more dangerous substances out there. Things like Carfentanil need to be regulated. So too all the so-called "date rape" drugs. Just because some guy wants a powerful, tasteless, anesthetic that can be readily dissolved in water doesn't mean we should let him have it. Even if it has personal uses, the danger of such substances means they need controls.
>> Control the action by the bad actor, not the drug.
That was what the legal system did in the 18th century. It didn't work. Allowing people to buy poisons, weapons, even explosives and only punishing them once they harmed others has been deemed unacceptable. We now prevent crime by limiting access to such substances, hand in hand with governments licensing who may access them. Don't like not having access to something? Become a doctor/chemist/soldier/miner and you will be legally free to play around with all sorts of dangerous things.
The problem with this logic as I see it is that you place the good/bad verdict in the hands of the gov. instead of the individual.
An example that comes to mind is Redbull and strike anywhere matches are banned in several countries. Both of these substances have been shown to be used responsibly in the majority of other countries.
Replace "government" with "society" (and centuries of moral philosophy too).
If all good/bad decisions were made by individuals, we'd basically have anarchy and rule of the strongest - as most people would probably decide that "good" is what benefits themselves and their close friends.
All decisions are ultimately made by individuals. There is no such thing as a group. Decisions made by a “group” benefit some and harm others that disagree. It is literally impossible to arrive at an ideal situation when you poll a group. Every individual has unique needs.
"Date rape" drugs seem rampant in certain communities but aren't used (hopefully) for rape but self-dosing at smaller amounts for their effects; regardless if they are legal or not the solution is the same: being safe in your behaviour and environment.
I don't know. It could be traumatizing to kill someone in a rather unspectacular car crash just because they weren't using their seatbelt. Same for helmets.
You may do so on your own private property. If you wish to use public roadways, you must abide by the laws set by your state, which must balance the costs to society of your choices against your ability to make them.
Drug use has one victim : the user. Time and time again it has been shown that legalization and cure are far more efficient and cost less to society but still many countries cling to the idea that beating up somebody who is down will magically solve the problem.
In which situation would you legitimately not want to wear a seatbelt while driving?
Will you also demand that individuals be capable of choosing - in that they have all the sufficient information to make an informed choice and are not manipulated by psychological tricks?
America has a penitentiary system, not a rehabilitation system. The concept of ruining lives with prison is embedded in the name, so there is a level of honesty, at least.
Manufacturing a substance harms no one. Distributing a substance to willing participants harms no one. possession harms no one. Use may harm the willing participant but I would argue for the freedom of that participant to make that choice.
It's well worth listening to.
The first episode of the series can be heard here: [1],[2]
[1] - https://psychedelicsalon.com/podcast-609-the-rose-garden-int...
[2] - Direct link to the mp3: https://media.blubrry.com/psychedelic_salon/archive.org/down...