Not having a github profile is fine and should raise no eyebrows same way not having a linkedin profile is fine. Resumes used to be a thing before linkedin and if someone says they don't have a resume then maybe that's an issue but otherwise it's business as usual. Similarly if a programmer has no side projects then that might or might not be a type of person you're trying to hire but github in no way is a prerequisite for having side projects which is what actually matters and is an indicator of how much a person invests in programming as a skill.
