Not at an interview, but I've certainly been asked about it in the informal social conversations that often are the precursors to eventual formal interviews, and people often seem skeptical when I say I don't have one (much in the same ways some people might react skeptically if told that someone doesn't have a github account).
Not having a github profile is fine and should raise no eyebrows same way not having a linkedin profile is fine. Resumes used to be a thing before linkedin and if someone says they don't have a resume then maybe that's an issue but otherwise it's business as usual. Similarly if a programmer has no side projects then that might or might not be a type of person you're trying to hire but github in no way is a prerequisite for having side projects which is what actually matters and is an indicator of how much a person invests in programming as a skill.
