If you don't mind me asking, what is your diagnosis? I don't ask to be nosey, insulin sensitivity is something I'm extremely interested in and would just like to read more about this. The diabetes/inflammation connection especially is extremely interesting to me because I think it probably has some kind of connection to muscle protein synthesis and growing in general that I'd like to learn more about.
My official diagnosis is "atypical cystic fibrosis." It predisposes me to CFRD -- Cystic Fibrosis Related Diabetes -- which is neither Type I nor Type II diabetes, or so I have heard.
I did read an article on protein and the role it plays in insulin resistance. I have no idea how you think that connects to inflammation. Care to share?
Sure, but I want to be totally clear that I am totally not a scientist or anyone who knows what he is talking about before I do so. I just read a lot of nutritional science because I'm interested in it and so I've strung together some high level patterns. Reading quickly about CF and ACF, I don't think it's related to what I'm talking about, but I'll explain my thoughts on diabetes and how it connects to MPS and growth. I also want to make it clear I'm talking about adult-onset, type ii diabetes. So probably not CFRD, and probably not type i.
On a high level the pattern I see is that growing is one of many intense metabolic stressors, and that there are other things that can approximate that stress once you stop growing, specifically strength training, although I think other forms of fitness are probably helpful as well, though less so. Inflammation is the major biproduct of strength training, and is a crucial part of the muscle building process, and yet we don't think of this inflammation as unhealthy (unpleasant, sure) and it doesn't cause diabetes. The most anabolic diet you can eat is one that causes huge amounts of inflammation (high carbohydrate, high protein). So you have this intense metabolic stress of growing and then it stops in your early 20s and you keep up the inflammation cycles with the same diet and you get diabetes. You remove this metabolic stress without adding another one and inflammation is bad, you add it and it's good (crucial, even). And finally, someone who has low insulin resistance is going to be the most affected by a highly inflammatory diet. In a healthy person lowering your body fat percentage is one of the main ways you can increase your insulin sensitivity (and thus muscle building potential). Spiking your insulin is terrible if you are overweight, but it's great if you are trying to build muscle.
Anyway, that's all very vague and I'm just some dog on the internet, but I think basically there's a scientific opportunity to show that strenuous exercise, specifically strength training, can have a much bigger impact on metabolic syndrome than the science currently gives it credit for.
