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This paper from Africa Health Research Institute shows a 41x reduction in effectiveness of pfizer vaccine for omicron.

https://www.ahri.org/omicron-incompletely-escapes-immunity-i... https://www.ahri.org/wp-content/uploads/2021/12/MEDRXIV-2021...


This preprint also shows reduced antibody neutralization of omicron in comparison to delta (including for double vaccinated + previous infection).

Note the sample sizes for all these studies is small. 12 participants for the AHRI paper and 8 to 20 per group for this one.

https://www.medrxiv.org/content/10.1101/2021.12.07.21267432v...


Sample size doesn't really matter much in this kind of study.


Ideally you'd match it to some population of interest. For my own medical affairs, I don't care what grand-pappy's results are here, I want to know how cousin Tim fairs.


Why not? I’m no statistician, so my basic understanding is you should always prefer bigger sample sizes to ensure statistically significant findings.


This paper doesn't even attempt to measure effectiveness. It measures neutralization titers which is a totally different thing.


See: https://www.news-medical.net/news/20200731/Research-suggests...

In addition to immunity based on T cells, the HIT depends on how individuals are networked. The original 60-70% estimates were based on 100% of people being vulnerable and also a random distribution of individuals interacting. In reality a small fraction of the population will have many interactions and once they become immune those transmission vectors away and the average R number drops. So based on the latest research plus observations of the worst hit places, 20-25% seems plausible.


The Biggest Ideas in the Universe A physics tour de force by Sean Carroll https://www.youtube.com/watch?v=HI09kat_GeI&list=PLrxfgDEc2N...


How about if we insisted you have 1,000,000 USD to buy guns or alcohol?


Alternatively pass regulations to make private companies over a certain size report more.


The parent is giving an example where it is clear cut.


Nothing would stop them from tracking access based on location.


Websites are public. The act of publishing on one is an explicit opt-in.


Would this work with water flows?


Well there's hydropower (gravity) or tidal power (celestial bodies). Otherwise I don't think water can be focused the way wind can.


Once they publisher reaches near monopoly status this is censorship.


What? I'd be shocked if Amazon even published a majority of books sold. There is no way they are monopoly or even close. I looked and couldn't find reliable stats on it. Does anyone else have any?


A majority by number of unique titles, or by sales volume? I would not be surprised to see Amazon publishing a very large fraction of 'long-tail' (almost self-published) books, and these likely make up a large fraction of all titles published.


What about eBooks?


They don’t have a monopoly on book publishing though. Look at how many book publishers there are out there.


Amazon is insignificant as a book publisher. They could have a near monopoly on selling books, but even that is unlikely.


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