thanks for letting me know. I believe IPInfo rate limits based on IPs so unfortunately if you are behind NAT or something I suspect you might hit this much more easily. Will try to think of some options.
Amazing! The 2009 Lincoln & Joyce paper you cited catalyzes one bond per hour on average. (Doubling time = 1 hour, but only one bond between oligonucleotides needed to double.)
OP's Gianni et al 2026 paper connects 45 nucleotides, taking 72 days (1700 hours) to yield 0.2%.
The latter effort is like drawing the whole owl.
That is incredible patience. Without access to the full article, I read only the abstract. I wonder if they used simulations to narrow the candidates?
I think the Real Bug™ here comes from product-management: Nobody should be taking this kind of stochastic guess process and then just... 100% trusting the outcome with no feedback to the user and no way for the user to correct bad guesses.
For example, a prompt when opening the file like: "It's unclear what kind of data this is, here are a few options with a preview, pick which one you'd like me to use."
Annoying, but them's the breaks when you're making software and aren't willing to put in hard requirements about what it is expected to (not) operate on.
