one of my favorite books since high school. I remember mentioning it to my HS English teacher before class one day (20 years ago) and she amazed and surprised me by replying "oh that's one of my favorites!" It seemed like an esoteric book to me at the time, but her generation also knew of it. maybe the OP can share what they find interesting about it...
since most public companies are owned by multi billion dollar hedgefunds, they're not exactly pillars of democracy. and since privately owned businesses are a thing; its really not that big of a deal
This comment is tone-deaf to the unique (and effective? TBD) arrangement of the board OpenAI 501(c)3 without compensation and the company they regulate. Your comment strikes me as not appreciating the unusually civic-minded arrangement, at least superficially, that is enabling the current power play. Maybe read the boards letter more carefully and provide your reaction. You castigate them as “non-techies” - meaning… what?
and the lesson the ousted ones learn for their next incarnation is to create organizations that allow for more control and more flexibility in board arrangements. I run a 501c3 as well, there are limitations in board composition in that entity type
nothing tone deaf about that, they wanted a for profit and are going to make one now and want leave the same vector open
Reread it as not being a comment about OpenAI it was about the lesson learned by every onlooker and the ousted execs
VSI thermodynamics is my favorite so far, it covers statistical mechanics of gasses, Boltzmann distribution defn of temperature… if you don’t know what these concepts are, I am confident you can get a good intro from the VSI thermodynamics book.
The author referenced a paper from 2009 about the microRNAs and BK subunits: "Post-transcriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714263/
"Tolerance represents a critical component of addiction. The large conductance calcium-and voltage-activated potassium channel (BK) is a well-established alcohol target, and an important element in behavioral and molecular alcohol tolerance. We tested whether microRNA, a newly-discovered class of gene expression regulators, plays a role in the development of tolerance. We show that in adult mammalian brain alcohol upregulates microRNA (miR-9) and mediates post-transcriptional reorganization in BK mRNA splice variants by miR-9-dependent destabilization of BK mRNAs containing 3’UTRs with a miR-9 Recognition Element (MRE). Different splice variants encode BK isoforms with different alcohol sensitivities. Computational modeling indicates that this miR-9 dependent mechanism contributes to alcohol tolerance. Moreover, this mechanism can be extended to regulation of additional miR-9 targets relevant to alcohol abuse. Our results describe a novel mechanism of multiplex regulation of stability of alternatively spliced mRNA by miRNA in drug adaptation and neuronal plasticity."
In my experience it’s easier to measure and thus control the temperature of a thermal mass that is much much larger than both the sensors (thermocouples) attached to it and the samples inside of it.
The large thermal mass of the heating block in a traditional thermocycler vs the relatively tiny masses of the samples inside the pcr tubes contained within means that the samples are basically always at the temperature of the block, which means the control loop for the heating/cooling system can be modeled and controlled with just a PID feedback loop.
Most excellent. After systematically scraping the nyt homepage and exploring some (undocumented) apis, the author quantifies “how much of the homepage is straight news vs puff/opinion/other?”
