The worst thing about BER is that it's designed to replace Tegel, which is easily the most sensibly built major airport in Germany. Space-efficient, cheap to operate, high-throughput, built very quickly with limited resources to solve a specific problem.
Tegel has the charm of an old bus station, but efficient it is. My record was Berlin Schönhauser Allee to Munich East in 3 hours and 20 minutes. It can only get worse from there. The commute to BER alone will be at least 30-40 minutes longer.
Who gives a shit about "charm". Last year I had a connection that due to delays on the incoming flight left me with 8 minutes from the time we got shuttled into the terminal to the time my outgoing flight gate closed, and it wasn't even in the same terminal. I ran over to the other terminal, went through the insecurity controls, and made the flight, with several minutes of time to spare. I know of no other airport where something like that would be possible.