(1) Point me towards the studies that prove SSRI's are so much better than placebo in the sickest patients. I really want to change my mind, but when I read the literature-- it's almost like they just can't admit they were fooled? Plus--take away tri, and hetro-cyclic drugs--the arsenal of cures goes way down, along with patient count? There's a strong reason to protect anti-depressants?
(2) "Eli Lilly, the company behind Prozac, originally saw an entirely different future for its new drug. It was first tested as a treatment for high blood pressure, which worked in some animals but not in humans. Plan B was as an anti-obesity agent, but this didn't hold up either. When tested on psychotic patients and those hospitalised with depression, LY110141 - by now named Fluoxetine - had no obvious benefit, with a number of patients getting worse. Finally, Eli Lilly tested it on mild depressives. Five recruits tried it; all five cheered up. By 1999, it was providing Eli Lilly with more than 25 per cent of its $10bn revenue."
(2) "Eli Lilly, the company behind Prozac, originally saw an entirely different future for its new drug. It was first tested as a treatment for high blood pressure, which worked in some animals but not in humans. Plan B was as an anti-obesity agent, but this didn't hold up either. When tested on psychotic patients and those hospitalised with depression, LY110141 - by now named Fluoxetine - had no obvious benefit, with a number of patients getting worse. Finally, Eli Lilly tested it on mild depressives. Five recruits tried it; all five cheered up. By 1999, it was providing Eli Lilly with more than 25 per cent of its $10bn revenue."
http://www.theguardian.com/society/2007/may/13/socialcare.me...
(3) Hay--they might work? Too tired to debate!