Haven't read it fully, but the first thing that popped in my head - wouldn't Apple benefit from this? There was one very detailed article on how their object method lookup changed over the years, but can't find it right now (Objective C).
I'm not an expert in Objective C but I believe that all dispatch is done by a library call that accepts the receiver, the message name, and the arguments. This means that there isn't any place to store per-call-site data, such as the kind of caches used in this paper.
