Another interesting thing to measure is how much time developers spend editiing each file. A friend of mine did excatly that by installing a logger in the IDE of all members of a team of developers. Turns out large classes are in fact evil!
While I intuitively agree with the conclusion there, this analysis definitely doesn't prove it...
Of course more time was spent editing files with more lines of code. In fact, if your entire application was all contained in one file, I am willing to predict that you'd (shockingly) find that all of your time was spent editing that very same file!
We wrote a blog about it: http://fagblogg.mesan.no/how-bad-is-smelly-code/