Dr. Donald Unger won the 2009 Ig Nobel for demonstrating (N=1) that knuckle-cracking doesn't lead to arthritis, by cracking the knuckles of one hand daily for 60 years, and never cracking those of the other.
When I don't crack my knuckles regularly, they start to feel extremely stiff and experience a dull pain. There is no way I'd be able to stop myself from cracking one of my hands for that long. That really is extraordinary self-control.
http://tech.mit.edu/V129/N41/ignobels.html