A friend, born in the early nineties, recently told me that she watched Californication first and, trying to later watch (the original) X-Files simply couldn't take Duchovny-as-Mulder seriously having been primed by Duchovny-as-Moody.
It's funny how some actors always seem to be themselves, not matter what role or character they play. E.g. whenever I see Martin Freeman in anything, I see him as Tim Canterbury (The Office UK).