ZFS has supported autodetecting 4k drives since day one, with the caveat that certain drives that were programmed to try to fool OSes that only supported 512 byte sectors would occasionally fool ZFS as well [1]. Additionally, ZFS can be set as case-insensitive, to match HFS+ behavior. Finally, I'd argue that ZFS is useful even to the one-drive user. The snapshot feature would make Time Machine backups even more transparent, compression would make things a bit smaller, and filesystem sending/receiving would make backing up to other devices a lot simpler. Modern filesystems just make sense, even for the regular user.
[1] http://blog.delphix.com/gwilson/2012/11/15/4k-sectors-and-zf...