You can change that easily, with izip from itertools.
The fact that a bunch of builtins and the values/items methods of dictionaries have become iterators is not very siginificant IMHO. Python 2 code could already be written to use iterators or generator expressions, so in the parts where it was crucial it was already done. In this regard Python 3 has not added new functionality but only changed defaults.
In this case (checking that process(input) == output), itertools.izip_longest is probably that right solution, unless there's an out-of-band way to know that inputs.txt is the same length as outputs.txt.
The fact that a bunch of builtins and the values/items methods of dictionaries have become iterators is not very siginificant IMHO. Python 2 code could already be written to use iterators or generator expressions, so in the parts where it was crucial it was already done. In this regard Python 3 has not added new functionality but only changed defaults.
The unicode change is the big one.