I'm still not sure why folks still use MyISAM. I'm sure there may be some edge case where it makes more sense, but in generally InnoDB seems like a better choice (not just regarding row level locking). Or postgres:)
That's my experience too. We have a few databases of about 500MB-1000MB each. They are running on MyISAM and don't use transactions, foreign keys, constraints or really any kind of database feature other than indexes.
I spent some time optimising it, not a lot of time, maybe a few hours over the course of a year. And even then mostly due to changing machines. It was quite easy to do, reading the manual page and increasing some buffers and so on. Nothing too complex.
We were running into problems in terms of server capacity. On the advise of a friend and just about every comparison on the Internet (notable exception there is the MySQL manual, BTW), we thought we'd give InnoDB a try. I read up on some of the configuration parameters, set some things to values that seemed sane and did a conversion.
Converting from MyISAM to InnoDB took over one hour for one database of about 800M. The server nearly died from that experiment. (Even though only one/tenth of the databases were switched over to InnoDB. The rest was still on MyISAM.) After a few hours to make sure it wasn't an accident, we switched back to MyISAM.
The most concise summary of the performance difference is probably given by comparing the conversion times. From MyISAM to InnoDB took over one hour (1 hour, 8 minutes, 10.74 seconds to be exact). From InnoDB to MyISAM took 2 minutes and 15.35 seconds.
The results were pretty terrible. Ever since I'm convinced InnoDB does not work well with our environment and application.
The big turn-off for me with MyISAM is that I can run a script to create some tables and setup for FK dependancies, and it will happily run it without errors, but won't enforce the constraints I created. Terrible behavior. I need foreign keys, transactions, row locking, etc...
I don't agree. MyISAM tables are easy to trash, and the table locking on update can bite you. There's no real disadvantage to using InnoDB other than having to learn to tune it a litte bit, and your data will be much safer.
MyISAM is like the ext2 filesystem. You crash and you end up spending a long time doing an fsck, where you have to verify the consistency by walking all the data structures. InnoDB is more like ext3, where you can make things consistent by replaying the changes in the journal. Doing repair on a large MyISAM table can take hours and hours.
The additional storage cost of InnoDB can be quite significant if you have a lot of data. We have about 4 billion rows in MyISAM, we simply wouldn't have space to do that with InnoDB.