First it's not a GUI Framework,it's a webview that uses a Python GUI framework with a PHP server. I bet one could create the exact same tool on top of node-webkit,since you'll be basically running a server.
The hell,you could do the exact same stuff with next to no "serverside" javascript by launching a PHP server yourself in node-webkit,with the advantage of using a better webview because i'm pretty sure the one used in wxPython is pretty old.
HTML/CSS is a GUI framework and besides you said it yourself:
Python GUI framework with PHP "bindings"
I don't think you should be dismissive of what the OP has done. You clearly believe this should be done differently. If that's the case I encourage you to spend your time and effort to do so just as the OP did. And then be brave enough to post your work on HN just as the OP was.
The hell,you could do the exact same stuff with next to no "serverside" javascript by launching a PHP server yourself in node-webkit,with the advantage of using a better webview because i'm pretty sure the one used in wxPython is pretty old.
edit:s/bindings/server