I hadn't seen Mithrill before, but from checking it out now it looks like it has a lot in common: small runtime, trying to be as close to plain JS and DOM as possible, and safety by default.
I'm not sure if it provides as much magic as Hamlet's auto-dependencies and template syntax, but those do have costs and tradeoffs.
I would like to see an interactive demo on the site so I could get to know it better by messing around.