I love using Acme with a three-button Trackpoint / nipple mouse, since I don't have to move my hand off home row. Trying to use a two-button mouse, or even one with a scrollwheel, is frustrating; my preferred solution is to map the [f1]...[f3] keys as mouse buttons.
An Acme idiom I use heavily is to create shell scripts in the root of a project's directory to diff, grep for the selected text, rebuild, etc. This essentially gives me a set of IDE buttons that are tailor-made for my current project.
Acme is the answer you give when someone asks "vim or emacs?"
Although I do not use it frequently at all (I alternate between editors), the use of mouse chording is really something that has not been explored enough in user interfaces.
An Acme idiom I use heavily is to create shell scripts in the root of a project's directory to diff, grep for the selected text, rebuild, etc. This essentially gives me a set of IDE buttons that are tailor-made for my current project.