Yes, in fact most common lisps support quite a bit more run-time features than Clojure does - like saving and restarting the image, conditions, etc. I found the uncommon-web screen casts to be very inspirational.
uncommon web was fantastic -- I haven't looked at it for a while, but the mailing list (which I'm subscribed to but no longer read) isn't too active. There do seem to be a few people still using and developing it though.
An approach like that for clojure would be a great thing IMO; that is, something different from the normal web framework approach, while exploiting the strengths of the clojure language and JVM ecosystem.
Same here with the casts, but actually making it work turned out to be quite a challenge. Weblocks looked a lot better, but it was still in development at the time. Since then I switched to clojure completely.
