I don't see you pointing out anything that is wrong?!
I also disagree that all that stuff should be obvious to everybody. Certainly wasnt to me, although it makes sense, which is why it's interesting. Rather than saying "hell, anybody can get cancer and we have no idea why" these guys seem to think about its role in evolution. They are thinking about it not as a random mutation but as an intentional genetic program which just makes much more sense.
Like in any criminal investigation, answering the cui bono question is imperative. I agree with the people in the paper actually: A deeper understanding is necessary. We dont know whether that will lead to a cure but as a software engineer its my experience that you can't fix a bug you don't understand. (And it amazes me so many of my fellow engineer try....)
I also disagree that all that stuff should be obvious to everybody.
It doesn't. But not everybody publishes something in journals. When you do, you have a responsibility to know your subject.
They are thinking about it not as a random mutation but as an intentional genetic program which just makes much more sense.
This actually makes little sense to me. The replication machinery and programming is deeply established, not a random mutation. The mutation is in the genes that regulate the system. The inappropriate execution of the replication is the key and that's well established to arise from mutational changes in regulatory elements.
I also disagree that all that stuff should be obvious to everybody. Certainly wasnt to me, although it makes sense, which is why it's interesting. Rather than saying "hell, anybody can get cancer and we have no idea why" these guys seem to think about its role in evolution. They are thinking about it not as a random mutation but as an intentional genetic program which just makes much more sense.
Like in any criminal investigation, answering the cui bono question is imperative. I agree with the people in the paper actually: A deeper understanding is necessary. We dont know whether that will lead to a cure but as a software engineer its my experience that you can't fix a bug you don't understand. (And it amazes me so many of my fellow engineer try....)