I've been using Live Bookmarks in Firefox, but it gets unwieldy past a number of feeds. Besides, it can be distracting to have it at the top of my browser window.
I'm always surprised by how few people recommend Vienna. If you're on the Mac and you're a power user, there just isn't another RSS reader that gets the shortcut keys right. It even has slight variations on how some of the navigation works, so you can pick what you like most. I use space to go through my feeds, occasionally hitting shift-space to go backwards to something I skipped over. For RSS feeds of sites like news.yc, I can glance over all the articles and hit s to mark the whole folder as read. ⌘-z undos your last action. I've got 93 feeds, which I guess isn't a whole lot compared to some nuts, but it works great for me.
The only thing it doesn't have is a way to sync between computers, but I don't need that.
"... but it gets unwieldy past a number of feeds. Besides, it can be distracting to have it at the top of my browser window. ..."
Are there any 'webapps' that personalise your feeds (url, return number), summarise (title, description, link) them and give you a page to view? (update: maybe http://www.bloglines.com ?)
Netnewswire (lite) until I realized that RSS was an even greater timesuck than this site. I still have it on my dock, but haven't been brave enough to start it up in a few months (the idea of seeing 4359683^34 unread articles when I boot it isn't a big motivator either).
SeekSift.com (disclaimer: this is my current project) which is more than just a feed reader, since it provides filtering and (coming soon) personalized recommendations.
Feedreader on PC, only because some of my feeds require passwords, and online ones don't seem to support that too well. Used to be bloglines before that requirement.
rss2email - get RSS articles by email. Put it in your crontab and let it get messages for you. Avoid annoying ads and stupid layouts by reading it in a text mail client. It's great.
Same here, with subscriptions (feeds) sorted in folders (for topics) and by Attention, a great way for feeds you end up reading/clicking a lot to bubble to the top of your reading list.