I did a quick test on some JSON data I use in my webapps; ~100k-1M blobs, mostly numbers. gzipped MessagePack data was just about the same size as gzipped JSON data. If you care about size on the wire over HTTP, then MessagePack may not be an improvement. It's amazing how well gzip compresses the stupid ASCII encoding of numbers in JSON.
Doesn't have to be stupid. A normal integer in binary representation ALWAYS consumes 4 bytes. With string representation you have 1000 numbers that will beat that as they only need <=3 characters. Numbers in that range are actually used very frequently.
Funny you should mention that. Msgpack uses a variable-length binary encoding for integers. It can, for example, fit integers in the interval [-32, 127] into a single byte. And unlike that fixed four-byte encoding you mention, it can also handle 64-bit integers.
(I'm not disagreeing with you, or anything. I just like talking about binary encodings.)