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Problem with p doom is I have no way to seriously evaluate anyone's percentage. The best I can do is rely on experts in a given field, like the recent virologist making a convincing case that no teenager is going to be prompting a doomsday virus into existence, because one doesn't exist and is unlikely to be made. There are too many biological tradeoffs and extremely difficult steps to doing so.

So I'm going to assume that the p doom for bioweapons is 0 in terms of existential threat (pandemics kill millions but not everyone).

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