He considers it safe if it's unlikely to crash? That's also true in C. Calling printf in a C signal handler is likely to work. So why does he consider it important in C but "not a practical consideration" in Python? It's more likely to crash in Python than in C because the signal handler takes longer to execute.
The article mentions that the Python handler is run outside of the C handler context and so is not subject to the C safety restrictions. It will not crash since the interpreter only calls the Python handler when it is safe. It will however not protect against reentrancy issues in the Python handler.
