Fascinating! I have non-hearing damage induced Tinnitus and Bipolar Disorder and have been interesting in my PDE genetics for sometime as a link to my issues. It seems I have a natural inhibition of many PDE genes (PDE4B specifically, but I have some less studied changes in my PDE5A genetics which suggests an inhibition there as well).
Sildenafil has been know to make BP people relapse in one case...
Sildenafil has been know to make BP people relapse in one case...
https://academic.oup.com/ijnp/article/7/4/525/707950?login=f...
And also investigated with some mood issues...
https://link.springer.com/article/10.1007/s00213-023-06361-3
Zinc and Magnesium are cofactors for all the PDE genes and those have helped me, specifically the zinc.
I have a feeling that low GTP is causing issues in ED since Cyclic GMP is made from GTP.