> If Ozempic is so great then how come our bodies don't just produce more GLP-1?
To store calories so you don't starve. This is a failure mode of evolution and there is in fact "free lunch" when we use technology to reoptimise our bodies to calorie abundance
> when we use technology to reoptimise our bodies to calorie abundance
replace "calorie abundance" with "sedentary lifestyle" and youre there. its people eating more than they burn off because they dont exert themselves because thats what being an adult means.
For part of my life, I was extremely athletic, and after five kids, I did not have time for 6+ hours a day of exercise. Doing one hour per day seemed to do nothing to offset middle age metabolism combined with a high carbohydrate diet.
The interesting thing is that once I switched to a keto diet, my body mass changed and my health improved significantly for the better. The interesting thing is that the keto diet is actually higher calorie than the high carbohydrate one.
I suspect that telling people they need to exercise more is not helpful - most people will never be able to exercise at a level that will make a dent in their diet. A lot of people are eating 4,000+ calories a day of high carbohydrate diet burning 50-200 calories per hour. The math just doesn't work. The diet is where it is at.
I imagine a hunter gatherer doing one hour of physical activity a day would not survive for long. Your body is probably working as intended. It is your lifestyle that is incompatible not the other way around.
Plenty of ways around it. Some people have a treadmill or spin bike desk setup. Powerlifting doesn’t take much time. You can also eat less.
You can't outrun a bad diet. You can easily out-eat any exercise though. Check just how few calories stationary cycling for an hour burns. I can eat that many calories in 5 minutes.
Calorie abundance is accurate too, food has never been as cheap and delicious as it is now. Not to mention the ultra-processed high-density foods we have now.
Meaning you can easily overeat with an active lifestyle too. In fact we have entire sports in which it's beneficial to do so.
(Rugby/American Football, Strongman competitions and Sumo wrestling to name a few obvious ones)
Not just delicious...dangerously, addictively, delicious.
I don't by Doritos because for me, any size bag is one serving.
On Zepbound and it's stunning how my favorite beer...the one I craved and tasted so good 'why don't I have another?'...no longer has a hold on me. I could take two or three sips, set it down, and walk away.
I also now feel full, but not disgustingly over-stuffed now.
> replace "calorie abundance" with "sedentary lifestyle" and youre there
Our lifespans have increased with our sedentary lifestyles.
Exercise is part of it. But we’re clearly working to transcend our natural health spans in a comfortable, modern environment. That will require the application of intelligence to the problem, not just brute force.
To store calories so you don't starve. This is a failure mode of evolution and there is in fact "free lunch" when we use technology to reoptimise our bodies to calorie abundance