> No, on the fact that there are plenty of known variants which increase the chance of lung cancer quite dramatically - moreso than smoking.
But didn't you just say that it is the genetics and not the radon and/or smoking? Can you give some examples of those "plenty of known variants" for lung cancer?
EGFR, as mentioned - it’s the most common cause of lung cancer in East Asian women.
TP53, as also mentioned - gives you a >90% chance of cancer of any variety in a lifetime. 50% by age 30.
Smoking presents about a 20% lifetime risk - and that’s without adjusting for genetic predispositions like CHRNA3/5 which increase nicotine addictiveness and promote tumorigenisis, or BRCA2, or CHEK2, which diminish DNA repair capabilities.
Quite strong claims. I would be interested to read more about those. Do you have any references you can point out? A quick research on EGFR and TP53 suggested they are more related to colorectal cancer and not the lung cancer.
But didn't you just say that it is the genetics and not the radon and/or smoking? Can you give some examples of those "plenty of known variants" for lung cancer?