If you're looking to move away from Chrome, Firefox + uBlock Origin is still your best bet IMO. Mozilla's committed to keeping the robust ad-blocking capabilities alive despite Google's changes.
Brave is decent too if you want something Chromium-based but more privacy-focused (comes with minor controversies).
Safari works well if you're in the Apple ecosystem.
I actually run a dual-browser setup these days - Firefox for most browsing, and only fire up Brave for those annoying sites that Google has mysteriously "optimized" to run poorly elsewhere. Not ideal but gets the job done!
What are you using instead?