I've never used Quarto, but I might give it a go someday. I currently have a convoluted workflow for generating math-heavy documents that involves generating equations using SymPy in a notebook, accumulating them in a string, and ultimately dumping the string into a Markdown. I would love to simplify this sooner rather than later. I'm also keeping an eye on https://typst.app/ and hoping for a sane alternative to LaTeX to emerge.