Love this question! Really touches on some epistemological roots and certainly a prescient question in these times. I can certainly see a theoretical where we could create this simulation in totality to our perspectives and then venture out into the universe to find that this modality of intelligence would be limited in its understanding of completely new empirical experiences/phenomenon that are outside our current natural definitions/descriptions. To add to this question: might we be similarly limited in our ability to perceive these alien phenomena? I would love to read a short story or treatise on this idea!