Fat cells 'remember' being bigger–and act like it

[anonnon]

https://www.science.org/content/article/fat-cells-remember-being-bigger-and-act-it

[wumeow]

> When a person gains weight, the number of fat-storing cells in their body doesn’t change; instead, each one expands to store more fat within it by changing the way it responds to and stores nutrients.

Is this true? I thought the number of fat cells increase when you gain weight but don't decrease when you lose it.

https://pubmed.ncbi.nlm.nih.gov/29991030/

> A decrease in body weight only changes fat cell size (becoming smaller), whereas an increase in body weight causes elevation of both fat cell size and number in adults.

[anonnon → wumeow]

Supposedly adipocyte hyperplasia is even more common during childhood weight gain.

[anonnon]

Link to the paper: https://www.nature.com/articles/s41586-024-08165-7

[bdangubic]

my fat cells never forgot so there is nothing to remember :)