I believe one can readily agree that https://example.com/profiles/gooosle and https://example.com/profiles/mdaniel are not sequential and thus not subject to enumeration in any reasonable way. A concrete example of defense against this is: please link to the HN username of an account which has never posted
It's not, by itself, deadly but it does lower the safeguards against ACL slip-ups, which could easily exfiltrate the entire customer base