Yes! I use mutt for searching, tagging, thread operations (splitting,appending etc.), bouncing, attaching other mails, deleting attachments, openpgp (personal), smime (at work), and it works with IMAP out of the box.
I am also able to integrate (a locally hosted) LanguageTool to check the grammar in the editor.
The only issue is to write emails with embedded images. But personally I don't like such emails for occupying the space of the mailbox.
Personnaly, I use https://gitlab.com/shackra/goimapnotify , you can add a `~/.config/imapnotify/{{ youremailaddresshere }}.yaml` config file for each of your email addresses and enable and start it as a systemd service with `systemctl --user enable ---now goimapnotify@{{ youremailaddresshere }}.service`
Here is and example of a config file for a gmail address :
Being able to select emails using regular expressions is super useful.
IMAPFilter is also simple and powerful to quickly sort email.