Mosquitos are a food source for some reptiles, fish, birds, and other insects and male mosquitos also serve as pollinators, of which many a species are already in danger.
When people talk about mosquito eradication programs, they're talking about subspecies that suck blood and carry the major diseases like malaria. Not all mosquitos.
That line of reasoning neglects the fact that there is very little control in such systems that differentiate between the subspecies.
CRISPR for example has been hailed as surgical tool for slicing DNA, and works well in controlled environments because we set up methodology and environment to guarantee it.
This has lead many outside the related fields to believe that the tool alone has more control than it does. In reality, any changes with these tools must be formally verified through plasmid sequencing. This is Plasmidsaurus business model, and they are quite good at it.
Even afterwards though, outside very specific conditions (which are often involved in keeping it cold and below certain safety thresholds), unstable changes can occur, the effects of which we will never know beforehand. A shift by 1 base (3 bases per codon) may alter an entire sequence, but the molecular machinery would continue running until it is stopped.
It may result in death of the mosquito, and/or provide material (shedding/ingestion) that may be taken in by other unrelated species with unknown consequence.
Who is to say what impacts that might have, and with each additional node (mosquito), the chance of such outcomes increase greatly. To my knowledge, there have been very few studies that cover the topic of genomic stability with regards to CRISPR and its related tools. This is an area with extremely low visibility to potential consequences.
The very last outcome we want is for animals to attain a defiant pupil, along the plot line of Zoo.
