Imagine you want to glue together something to use with a syncing tool. ~100 lines of python can turn data from one format into a presented set of files. The application doesn't have to be a general purpose filesystem.
A operating systems class I was once a lab assistant for, we implemented the key parts of an operating system in Python. Scheduler, Filesystem, Memory Management. I think it ended up being more confusing than not, but I appreciated where it could go.