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I think we desperately need to answer the question of why GLP-1 agonists are so effective, and particularly whether it's counteracting something in the environment that has been acting to reduce GLP-1 (or other glucagon-related pathway) activity without us realizing it. The obesity data practically screams that something happened in North America ca. 1980 that messed up our metabolisms, and it may have spread to Europe after a delay. Unfortunately, it seems like one of those things where there are various people with pet theories and little substantial effort to get to the ground truth. Perhaps the inevitable search for "me-too drugs" will uncover something.



Europe has been climbing at a steady rate since at least 1975.

https://www.europeandatajournalism.eu/cp_data_news/europe-fa...


Coke and Pepsi started using HFCS in 1980.

I’d be curious about side effects of the Depression and WW2 that took an extra generation to show up.


> I’d be curious about side effects of the Depression and WW2 that took an extra generation to show up.

While there might be a time span involved that could be described that way, as far as I've read there weren't any statistics that were "generational" in the usual sense of the term. Obesity rates started rising among all age groups at roughly the same time.


Hormones in meat. And I expect the women's pregnancy pill plays a part in this as well to why we have over emotional disorders. This has all originated from the 70's both.

The demand for cattle are so high that they force feed them growth hormones. You eat the meat, you end up with injected mutations and then over generations you then end up with people with growth hormones and obesity because of.

How can hormone bated meat not affect the human body?

As well, women have been taking a pill, since the 70's, it does its thing, they pee. That mixes with the water and overtime pollutes the generations.


Glyphosate was introduced around that timeline.


One aspect is that the US food system as a crap ton of UPF.


UPF means "ultra-processed foods", in case anyone else had to look it up like I did.


How does that cause the rest of the world to also have decades-long steadily increasing obesity rates?




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