Expo makes it super easy to get started with React Native, offering quick setup, built-in tools, and easy updates, which is great for simple apps or prototypes. However, it comes with some limitations, like larger app sizes and less flexibility with native code. On the flip side, using bare React Native gives you complete control, better performance, and access to the latest features, but it requires more setup and can be a bit more challenging. The choice really depends on whether you need speed and simplicity or full control and customization.