Regular Glucosamine Use and Mortality

[libpcap]

https://ard.bmj.com/content/79/6/829

[zihotki]

From the article:

>> regular glucosamine use may be a marker for a healthy lifestyle, but it is hard to distinguish the confounding effects of a healthy lifestyle from the impact of regular supplementations in an observational study.

[LorenPechtel → zihotki]

Yeah, everything about such longevity studies has such obvious confounders that it seems pretty much useless.

[chaostheory → LorenPechtel]

It might enable you to have a healthier lifestyle since it helps with mobility.

[cryptichash]

Based on a quick survey [1], seems like various forms of glucosamine are not interchangeable. Doesn't this confound the study further given its unclear which supplements led to what outcomes?

[1] https://www.mayoclinic.org/drugs-supplements-glucosamine/art...

[dave333]

Glucosamine seems to be taken to treat joint pain and osteoarthritis but would a general anti-inflammatory effect be what causes a reduction in mortality if any?

[ImHereToVote → dave333]

Isn't Glucosamine needed for Hyaluronic Acid synthesis. Hyaluronic Acid essentially keeps tissues moisturized.

[vjerancrnjak]

Interesting preliminary investigation but there’s no mathematics that can remove confounding factors for such small effects.

[drxzcl → vjerancrnjak]

It’s 500k people for over a decade. If any study has the data to do it, it’s this one.

[LorenPechtel → drxzcl]

Sample size is useless at removing confounders.

[zihotki → drxzcl]

It's an observational study. You can't make conclusions based on it. But it can be a basis for more detailed study.

[OutOfHere]

Glucosamine and independently chondroitin can provoke a slight allergic reaction. That's because they're often sea derived. Perhaps lab synthesized versions wouldn't have this issue. The reaction, although not serious, can be enough to discourage their use.

[LeoPanthera]

For me this URL leads to a Wordpress login page.

[beefman]

(2020)

[WalterSear]

This is from 2020.

[Khelavaster]

What if everyone got enough glycine while their blood sugar was adequate, so that their glucosamine levels topped up...

[zingababba → Khelavaster]

Supplemental glycine instantly gives me crippling insomnia. Even magnesium glycinate or anything else bound to it causes issues.

[OutOfHere → zingababba]

Collagen hydrolysate is a better source for getting the benefits of glycine than is pure glycine.

[Khelavaster → zingababba]

glycine needs to be taken with lysine and vitamin C to keep from depleting lysine into collagen..

[zingababba → Khelavaster]

Interesting, thanks.

[amelius]

> The inverse associations of glucosamine use with all-cause mortality seemed to be somewhat stronger among current than non-current smokers

So take glucosamine and start smoking? /s