I would probably look at apps other than Chrome. There's "unaware of the retina display", and there's "we eschewed native APIs to some extent and rolled our own implementations of stuff".
I don't know if this is the case, exactly, with Chrome. I'm just saying it might not be wise to generalize from Chrome's appearance to retina-naive 3rd party apps in general.
> I don't know if this is the case, exactly, with Chrome
As part of its security model, Chrome does something akin to rendering everything offscreen in an unprivileged process then passing that to the user-facing process.
In other words, it depends but it most certainly will have its share of issues, question is for how long.