- If I'm reading correctly, they classified someone's diet mostly based on 1 single prior 24 hour food questionnaire. This is a bit...weak.
- The LCHF cohort has significant pre-existing conditions (which they do correct for, but their headline is about the non-corrected number)
- They define LCHF diets as being <100g of carbs a day, and define VLC diets as being <50g a day, but do NOT publish any results for the VLC cohort. Why not?
- They then do NOT publish their data!
- BUT if you dig into their supplementary tables, they DO report that VLCs have lower rates of ASCVD than LCHF.
- They have conflicts of interest: "Dr Brunham has served on advisory boards for Amgen, Novartis, HLS Therapeutics, and Ultragenyx. Dr Iatan has served on advisory boards for Novartis and HLS Therapeutics and receiving honoraria from Novartis and Sanofi. "
Anyway, I give that one a C-. Well executed, but looks like their hands are tied. I would not bet on its associations to reproduce in an experiment.
We can pick apart studies all day long, but the link between saturated fat and cholesterol is hard to deny.
Were I you I would get my ApoB checked. If it’s low, then great! Keep doing what you’re doing! But don’t give yourself a heart attack following the latest fad diet.
I definitely do _not_ understand the first thing about cholesterol and adverse cardiovascular events.
Certainly high on my list of things to be able to model by the end of the year.
I have spent a fair amount of time in the lab (mostly dry, with a little bit of wet lab), so have good foundations, just that's an area I haven't had time to deep dive in yet.
Dataset needed