The EPA values one human life at $10M. A conservative estimate of the number of people killed by the Sackler family's companies (testified in court) was ~~245,000~~ Edit: probably at least 100,000, see below. So if opiates were environmental pollutants, the Sacklers would be on the hook for $1T in damages. Their immediate settlement was $6B.
The number of opioid overdoses between 1999 and 2021 was 645,000, according to CDC. Purdue Pharma brought in $35B in OxyContin revenue from 1995 to 2017. OxyContin was prescribed to 6.2 million people in 2002.
I'll edit the number above to ~100,000 as an estimate of the number of victims, since it looks like I misremembered 645,000 as the number of Purdue-related deaths. Still, that's assuming only 1.6% of those 6.2 million people taking OxyContin in 2002 developed an addiction, which seems low.
Roughly three orders of magnitude too small.