You usually don't find I2C in the high end space-rated parts simply due to the added complexity of a simplex protocol but you see tons of single-ended SPI parts. You don't need diff pairs unless it's for high speed or long cable runs. If your controller (FPGA, microcontroller, etc) has the resources, a good idea is to have a single SPI slave per master. Also since SPI is not standardized, vendors may have different signaling requirements which makes it slightly more difficult to put different chips on the same bus. Talking to SPI chips is super easy and can be implemented entirely in 7400-series logic if you want so it's entirely possible to have analog electronics send control signals to SPI devices without a single CPU in sight.
